mRNA display: from basic principles to macrocycle drug discovery.
about
Peptide library approach to uncover phosphomimetic inhibitors of the BRCA1 C-terminal domainHigh-Throughput Approaches to the Development of Molecular Imaging Agents.Drug discovery: Combichem all over again.Conceptual and methodological advances in cell-free directed evolution.Dihydrofolate reductase inhibitory peptides screened from a structured designed β-loop peptide library displayed on phage.Preferential germline usage and VH/VL pairing observed in human antibodies selected by mRNA display.PURE mRNA display for in vitro selection of single-chain antibodies.Automated screening for small organic ligands using DNA-encoded chemical libraries.Tumor-targeting peptides from combinatorial libraries.Ribosomal Synthesis of Thioether-Bridged Bicyclic Peptides.A Shorter Route to Antibody Binders via Quantitative in vitro Bead-Display Screening and Consensus Analysis.Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules.Enhanced mRNA-protein fusion efficiency of a single-domain antibody by selection of mRNA display with additional random sequences in the terminal translated regions.Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases.Targeting intracellular protein-protein interactions with cell-permeable cyclic peptides.Enhancement of the in vivo persistence and antitumor efficacy of CD19 chimeric antigen receptor T cells through the delivery of modified TERT mRNA.Assessing histidine tags for recruiting deoxyribozymes to catalyze peptide and protein modification reactionsDirected evolution of anti-HER2 DARPins by SNAP display reveals stability/function trade-offs in the selection processComplementary DNA display selection of high-affinity peptides binding the vacuolating toxin (VacA) of Helicobacter pylori.Macrocycles: lessons from the distant past, recent developments, and future directions.Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides.Overview of cell-free protein synthesis: historic landmarks, commercial systems, and expanding applications.Genetic incorporation of 4-fluorohistidine into peptides enables selective affinity purification.Directed Evolution of Glycopeptides Using mRNA Display.Progress towards the broad use of non-peptide synthetic macrocycles in drug discovery.Max Bergmann award lecture:Macromolecular medicinal chemistry as applied to metabolic diseases.Non-competitive cyclic peptides for targeting enzyme-substrate complexes.Synthetic fermentation of β-peptide macrocycles by thiadiazole-forming ring-closing reactions.Model foldamers: applications and structures of stable macrocyclic peptides identified using in vitro selection
P2860
Q28256541-15A418D0-225D-41CD-815E-32A2C65A7D19Q30275493-36C1A85C-D7DA-45D7-AF68-5BEC39201DA7Q35267948-15FF1622-5DEA-4100-91E6-B63A8B48E3EBQ35669418-C5C6945B-3B0C-4ABF-9672-C2C6FD943A6DQ35676500-7FE571E3-FA4B-465E-AFC1-D166EB13451CQ35763923-01AE8F30-58F0-4EEC-8778-56F2B3893D94Q35879962-BF15446B-BBF6-4743-8979-77CFEECD283BQ35960349-746BBEBD-BF8D-4A6B-9FE7-F759349337A3Q36025723-C60D9C69-07A8-4CDC-87F6-93DD71F60D28Q36156160-08746984-C1E3-4F2E-AB9F-4F0F8A18A3EEQ36183984-EE3C0E65-C525-49D6-B770-69FB28709485Q36242161-9482DEDD-66D7-4838-A7E1-77EB6805FE03Q36301575-6B065FDA-5F19-4AE9-83B7-08F5FBED7BB7Q36331476-257A7FFE-7E04-43C5-8EDA-CF5C48825D30Q36339706-D62906EE-7E57-4E2F-ACFE-631327449F4BQ36882726-57F21959-63D3-463A-91BA-DCE2F61892ACQ36916702-C89DBABE-E66F-4741-B2A7-9F64B9596567Q38857819-08B2A5ED-D427-4099-913E-EBE18F96D71DQ39059191-D446A841-4D24-4B83-A76A-7BD61F4936ABQ39065925-7B78E3BA-DF2F-40AF-A954-E42DA3873168Q41077825-CE61C26B-011F-4B59-9517-C22A3580868EQ42549080-100BE316-9454-4B3A-BFE5-EC5BB14915FAQ45059337-0E0C97A6-81DB-4090-8A27-2086F17D3BADQ47765958-6A776D9F-7953-4318-892E-D150F103762EQ47849835-87A9CBFD-4406-4F02-A899-E1C057426121Q48262310-6A69A6A5-1402-4DA7-BBCA-BF5D2F6699B9Q55083155-46309E08-3542-42DC-99EA-7CF1A3E7A7EEQ55365864-592E1A8B-947A-40C2-981E-531FE6B7863EQ57840920-BDA072E3-FB74-469F-B53D-4C48BC6411DE
P2860
mRNA display: from basic principles to macrocycle drug discovery.
description
2013 nî lūn-bûn
@nan
2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
mRNA display: from basic principles to macrocycle drug discovery.
@ast
mRNA display: from basic principles to macrocycle drug discovery.
@en
type
label
mRNA display: from basic principles to macrocycle drug discovery.
@ast
mRNA display: from basic principles to macrocycle drug discovery.
@en
prefLabel
mRNA display: from basic principles to macrocycle drug discovery.
@ast
mRNA display: from basic principles to macrocycle drug discovery.
@en
P1433
P1476
mRNA display: from basic principles to macrocycle drug discovery.
@en
P2093
Alonso Ricardo
Kristopher Josephson
P304
P356
10.1016/J.DRUDIS.2013.10.011
P50
P577
2013-10-22T00:00:00Z