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Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging

Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging

http://www.wikidata.org/entity/Q35027745

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ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases Cellular Senescence as the Causal Nexus of Aging Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis Mitochondrial DNA Hypomethylation Is a Biomarker Associated with Induced Senescence in Human Fetal Heart Mesenchymal Stem Cells.Monoamine Oxidases, Oxidative Stress, and Altered Mitochondrial Dynamics in Cardiac Ageing Mechanisms and functions of Nrf2 signaling in Drosophila.Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing.NRMT1 knockout mice exhibit phenotypes associated with impaired DNA repair and premature aging.Cell Autonomous and Non-Autonomous Effects of Senescent Cells in the Skin.Age-Associated Lipidome Changes in Metaphase II Mouse Oocytes Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells Combined activation of the energy and cellular-defense pathways may explain the potent anti-senescence activity of methylene blue.Pharmacogenomic analysis indicates potential of 1,5-isoquinolinediol as a universal anti-aging agent for different tissues.Loss of BOSS Causes Shortened Lifespan with Mitochondrial Dysfunction in Drosophila From Ancient Pathways to Aging Cells-Connecting Metabolism and Cellular Senescence.The inhibitory mechanism of Cordyceps sinensis on cigarette smoke extract-induced senescence in human bronchial epithelial cells.Identification of Senescent Cells in the Bone Microenvironment.The Citrus Flavanone Naringenin Protects Myocardial Cells against Age-Associated Damage.Drosophila melanogaster Hsp22: a mitochondrial small heat shock protein influencing the aging process.Molecular pathology endpoints useful for aging studies.Mitochondrial responsibility in ageing process: innocent, suspect or guilty.Drosophila melanogaster mitochondrial Hsp22: a role in resistance to oxidative stress, aging and the mitochondrial unfolding protein response.Effects of bioactive compounds on senescence and components of senescence associated secretory phenotypes in vitro.Targeted apoptosis in ovarian cancer cells through mitochondrial dysfunction in response to Sambucus nigra agglutinin.The slim, the fat, and the obese: guess who lives the longest?The Emerging Role of Mitochondrial Targeting in Kidney Disease.Endoplasmic Reticulum-Mitochondrial Ca2+ Fluxes Underlying Cancer Cell Survival.Cardiometabolic phenotypes and mitochondrial DNA copy number in two cohorts of UK women.Effect of myricetin, pyrogallol, and phloroglucinol on yeast resistance to oxidative stress.Caveolin-1 deficiency induces premature senescence with mitochondrial dysfunction.The Preconditioning of Berberine Suppresses Hydrogen Peroxide-Induced Premature Senescence via Regulation of Sirtuin 1.Aging: Molecular Pathways and Implications on the Cardiovascular System.The path from mitochondrial ROS to aging runs through the mitochondrial permeability transition pore.A comparative perspective on longevity: the effect of body size dominates over ecology in moths.Mitochondrial Functional Changes Characterization in Young and Senescent Human Adipose Derived MSCs.Reproductive aging is associated with changes in oocyte mitochondrial dynamics, function, and mtDNA quantity.Living longer through mitochondrial housekeeping.Coenzyme Q10 inhibits the activation of pancreatic stellate cells through PI3K/AKT/mTOR signaling pathway.Lin28a enhances in vitro osteoblastic differentiation of human periosteum-derived cells.Empowering human cardiac progenitor cells by P2Y14 nucleotide receptor overexpression.

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Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging

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Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging

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Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans

A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.

Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1

Feedback between p21 and reactive oxygen production is necessary for cell senescence

SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells

Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

Regulation of ploidy and senescence by the AMPK-related kinase NUAK1

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

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