Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides.
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Modification of DNA by the benzo[a]pyrene metabolite diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene.Cell-specific induction of mouse Cyp1a1 mRNA during developmentExcision repair of benzo[a]pyrene-deoxyguanosine adducts in baby hamster kidney 21/C13 cells and in secondary mouse embryo fibroblasts C57BL/6J(+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo (a)pyrene: a potent skin carcinogen when applied topically to miceMutagenicity and cytotoxicity of benz[alpha]anthracene diol epoxides and tetrahydro-epoxides: exceptional activity of the bay region 1,2-epoxidesSpecificity of chemiluminescence in the metabolism of benzo[a]pyrene to its carcinogenic diol epoxide.Investigation of the genotoxicity of dibenzo[c,p]chrysene in human carcinoma MCF-7 cells in culture.c-Jun N-terminal kinase-mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forksMechanism of the inhibition of mutagenicity of a benzo[a]pyrene 7,8-diol 9,10-epoxide by riboflavin 5'-phosphateFungal oxidation of (+/-)-9,10-dihydroxy-9,10-dihydrobenzo[a]pyrene: formation of diastereomeric benzo[a]pyrene 9,10-diol 7,8-epoxides.Specificity in interaction of benzo[a]pyrene with nuclear macromolecules: implication of derivatives of two dihydrodiols in protein bindingCigarette side-stream smoke lung and bladder carcinogenesis: inducing mutagenic acrolein-DNA adducts, inhibiting DNA repair and enhancing anchorage-independent-growth cell transformation.Integrating S-phase checkpoint signaling with trans-lesion synthesis of bulky DNA adducts.The conduct of drug metabolism studies considered good practice (I): analytical systems and in vivo studiesIdentification of 7,12-dimethylbenz[a]anthracene metabolites that lead to mutagenesis in mammalian cells.Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.Identification of four trans-3,4-dihydrodiol metabolites of 7,12-dimethylbenz[a]anthracene and their in vitro DNA-binding activities upon further metabolism.Modulation of benzo[a]pyrene-DNA adduct formation by CYP1 inducer and inhibitor.In vivo and in vitro replication consequences of stereoisomeric benzo[a]pyrene-7,8-dihydrodiol 9,10-epoxide adducts on adenine N6 at the second position of N-ras codon 61.Translesion Synthesis: Insights into the Selection and Switching of DNA Polymerases.Novel drug metabolites produced by functionalization reactions: chemistry and toxicology.Benzo[a]pyrene carcinogenesis: a biochemical selection mechanism.Electron paramagnetic resonance study of the generation of reactive oxygen species catalysed by transition metals and quinoid redox cycling by inhalable ambient particulate matter.Rapid method for detection and quantitation of hydroxylated aromatic intermediates produced by microorganisms.Aryl hydrocarbon hydroxylase and benzo[a] pyrene metabolism in rodent liver and human cels.Studies on the metabolism of benzo[a]pyrene and dose-dependent differences in the mutagenic profile of its ultimate carcinogenic metabolite.Arachidonic acid-dependent metabolism of 7,8-dihydroxy-7,8-dihydro-benzo[a]pyrene by ram seminal vesicles.The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis.Multidrug resistance-associated proteins are involved in the transport of the glutathione conjugates of the ultimate carcinogen of benzo[a]pyrene in human Caco-2 cells.Quantitative RT-PCR measurement of cytochromes p450 1A1, 1B1, and 2B7, microsomal epoxide hydrolase, and NADPH oxidoreductase expression in lung cells of smokers and nonsmokers.Posters
P2860
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P2860
Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides.
description
1976 nî lūn-bûn
@nan
1976 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1976 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1976年の論文
@ja
1976年論文
@yue
1976年論文
@zh-hant
1976年論文
@zh-hk
1976年論文
@zh-mo
1976年論文
@zh-tw
1976年论文
@wuu
name
Metabolism of benzo[a]pyrene: ...... agenic 7,8-diol-9,10-epoxides.
@ast
Metabolism of benzo[a]pyrene: ...... agenic 7,8-diol-9,10-epoxides.
@en
type
label
Metabolism of benzo[a]pyrene: ...... agenic 7,8-diol-9,10-epoxides.
@ast
Metabolism of benzo[a]pyrene: ...... agenic 7,8-diol-9,10-epoxides.
@en
prefLabel
Metabolism of benzo[a]pyrene: ...... agenic 7,8-diol-9,10-epoxides.
@ast
Metabolism of benzo[a]pyrene: ...... agenic 7,8-diol-9,10-epoxides.
@en
P2093
P2860
P356
P1476
Metabolism of benzo[a]pyrene: ...... agenic 7,8-diol-9,10-epoxides.
@en
P2093
P2860
P304
P356
10.1073/PNAS.73.10.3381
P407
P577
1976-10-01T00:00:00Z