mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry - Wikidata - wikimedia - TriplyDB

mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry

mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry

http://www.wikidata.org/entity/Q35033877

about

mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR Differentially expressed proteins in malignant and benign adrenocortical tumors Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers.Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.Using immunomic approach to enhance tumor-associated autoantibody detection in diagnosis of hepatocellular carcinoma.Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IκB kinase α (IKKα).Glutamine stimulates biosynthesis and secretion of insulin-like growth factor 2 (IGF2), an autocrine regulator of beta cell mass and function.Use of Drosophila as an evaluation method reveals imp as a candidate gene for type 2 diabetes in rat locus Niddm22 RNA-binding protein insulin-like growth factor mRNA-binding protein 3 (IMP-3) promotes cell survival via insulin-like growth factor II signaling after ionizing radiation.MiR-216b is involved in pathogenesis and progression of hepatocellular carcinoma through HBx-miR-216b-IGF2BP2 signaling pathway Reassessment of the role of TSC, mTORC1 and microRNAs in amino acids-meditated translational control of TOP mRNAs.Transcriptome Dynamics and Potential Roles of Sox6 in the Postnatal Heart.Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells.Imp2 regulates GBM progression by activating IGF2/PI3K/Akt pathway.IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins.Mammalian target of rapamycin (mTOR) signaling network in skeletal myogenesis.mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts.Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis Prediction of functional phosphorylation sites by incorporating evolutionary information The rs11705701 G>A polymorphism of IGF2BP2 is associated with IGF2BP2 mRNA and protein levels in the visceral adipose tissue - a link to type 2 diabetes susceptibility.Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?Posttranscriptional regulation of insulin family ligands and receptors IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer.The role of mammalian target of rapamycin (mTOR) in the regulation of pancreatic β-cell mass: implications in the development of type-2 diabetes.Insulin-like growth factors and insulin: at the crossroad between tumor development and longevity.Regulation of β-cell function by RNA-binding proteins.Signaling crosstalk between the mTOR complexes.Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis.IGF2BP1: a novel binding protein of p38 MAPK.miR-1275: A single microRNA that targets the three IGF2-mRNA-binding proteins hindering tumor growth in hepatocellular carcinoma.Molecular mechanisms of mTOR regulation by stress Insulin-like Growth Factor 2 Overexpression Induces β-Cell Dysfunction and Increases Beta-cell Susceptibility to Damage.IGF2BP1 controls cell death and drug resistance in rhabdomyosarcomas by regulating translation of cIAP1.Post-transcriptional regulation of cyclins D1, D3 and G1 and proliferation of human cancer cells depend on IMP-3 nuclear localization.IGF2BP1 promotes mesenchymal cell properties and migration of tumor-derived cells by enhancing the expression of LEF1 and SNAI2 (SLUG).Oncogenic NRAS, required for pathogenesis of embryonic rhabdomyosarcoma, relies upon the HMGA2-IGF2BP2 pathway Identification of a novel promyelocytic leukemia zinc-finger isoform required for colorectal cancer cell growth and survival.Long Noncoding RNAs and RNA-Binding Proteins in Oxidative Stress, Cellular Senescence, and Age-Related Diseases.IGF2 mRNA binding protein-2 is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1

P2860

Q28270006-D25EBA91-FF1A-4416-84B3-7564A878DFA0 Q28539466-7FEC894F-D550-4878-BD8D-08561DBE2FC0 Q31038292-35EFEE34-18FA-4A37-80ED-7F94B959510C Q33668452-A50FBA8D-11ED-439B-AF94-7D4C4672CF28 Q33895858-6C8D80A2-0795-46D2-9505-787219C1907C Q34139142-26CC65F8-775F-4C67-9AC4-83AD53092FAC Q34509707-2B513948-B140-476B-9DAE-1C63366E7EE5 Q35188468-4249C026-ADA4-48EC-B463-8758E6BCA185 Q35213255-8338A988-785B-41B2-951E-9F854A555DD5 Q35274515-C59683F3-33D2-49E8-867E-66F8A2D29C4F Q35358625-CE5B84D6-7E2D-4BFA-AD53-F1ADC6BDD088 Q36188897-7571EC3D-123D-4A04-A4CB-E9A6BE068397 Q36213711-C16DB72B-7ACE-4288-9335-C313DEA8179B Q36214062-505E72B6-F7E2-4B4A-B39F-E90EE4C3512E Q36330965-D600CF9E-7BDA-4C3B-820B-4443DA42D6D7 Q36481912-FE2815CC-C58A-4658-A25E-0E1ECDD51C3A Q36621894-B37BE75C-EBDA-4A09-B61D-7F816E6B6F0B Q36820977-12BCA5F6-E55D-486F-8BDF-9AFA317CC515 Q36821086-BB3C4FCD-1EF4-47D0-9090-BDB177A4E837 Q36922913-2E1CBE7B-992A-473F-9168-F663F5CBD879 Q36978036-F8C0A5BD-3ABB-44AB-84FA-83919434CF60 Q37002361-A0B0E308-9CBE-40FE-A84A-E35E7139BA9B Q37225291-69B449D8-F283-4E29-B348-2527B991A555 Q37507920-485AE236-9750-49DA-A38F-4C3BE66FE1CB Q37954130-0A8DE371-784F-48D4-9D87-0587966AE81D Q37994048-7BA9ECDC-CE6C-46C8-A5FC-6DBA6BAAF53D Q38170369-6BA86F55-FED8-4A44-BE80-86C55B88A4AA Q38700659-6C9F0BA8-D6A0-4098-ADEE-9DA9CAA5D677 Q38717560-9E8C4BE8-53B7-4E7A-8FCF-4153B5CE56EA Q38790090-77054FB1-BA0D-4CFC-914D-4A3159E502D7 Q38854666-53C4A238-7FAC-409F-83E3-B0749296E787 Q38866763-DC134E8B-E5A4-4952-BDFC-ED08C8F2D710 Q38875279-D925BAA7-CDA8-4FFE-BEE4-B13BF1F662C0 Q39007414-C6A5BAA2-29C4-4234-85B5-41A4E83B3899 Q39133014-A06CAEA5-66EC-4DC7-AE9B-E2DA2A6BCCAA Q39151460-6B09E9AE-8515-44AD-B6B3-D84D01679BB5 Q39174563-FAC5DB88-FEDA-499E-ACA2-C98FECD78201 Q39217928-21843D31-2EA9-42FF-BCE9-CFEBB6BCC3F1 Q41294329-A5BB8482-2EAF-477F-B479-BBBAF73374B3 Q41559661-0E3C818C-464D-4163-80C9-63468F4C3ADF

P2860

mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry

http://www.wikidata.org/entity/Q35033877

description

2011 nî lūn-bûn

@nan

2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry

@ast

mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry

@en

type

label

mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry

@ast

mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry

@en

prefLabel

mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry

@ast

mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry

@en

P1433

Q35033877-0ED06BD5-CC85-42F8-8712-A4F1110040CF

P1476

Q35033877-92A543A6-CAFE-4C1F-B17F-C40545025BA2

P2093

Q35033877-0612A1E6-53F6-43F0-BD1C-275E4E9A4EFA

Q35033877-3798CDE9-288E-4715-B47A-BB230F9A37CE

Q35033877-4E2C0EF5-5A83-46FF-822B-EB66F3A91AA5

Q35033877-B4502EBF-2ECE-46B2-B720-50806FA771DF

Q35033877-D37839D9-B97B-41A7-9492-3362EB590062

Q35033877-D8C6D205-454B-468B-8C34-ABE82D1C5647

P2860

Q35033877-006B14FD-AB59-4D4D-A317-C07C7DF5B2BF

Q35033877-04F6400F-8CE6-4929-A576-65FD7B60DB5A

Q35033877-0A1DA8E1-5216-4E75-AFD0-533E31EC25B0

Q35033877-0E0B5694-A1CE-4AEB-BBE0-8CA96DC28401

Q35033877-1022638E-FDE9-452B-B916-B12AF5FD3CC9

Q35033877-14DF2C2E-B022-40D5-8C1E-402256A6F5B5

Q35033877-154C4AC2-44BA-4D8D-8A0E-1C13A7F2FE90

Q35033877-1C911D4D-A1C4-4CE6-8931-7C42DC51345E

Q35033877-1F219674-E48A-424A-AFEA-65667319C620

Q35033877-23616CAF-C25A-4983-AA82-CF60ABDE1668

P304

Q35033877-7888F692-51FE-4E02-B9DF-98C080C733B9

P31

Q35033877-CCBABEB9-F51D-4B8D-B8A7-588672D139F5

P356

Q35033877-EA618F18-EBFC-4590-A752-8750FE400181

P433

Q35033877-46CC3D3F-776F-4AAF-BBE1-1A067F718A62

P478

Q35033877-7D4F831D-3416-45DD-A984-F003923E2029

P577

Q35033877-FF9656B0-F628-4C2E-B858-FB233022698F

P5875

Q35033877-A38E0139-2F30-4C56-B140-456DD310C5E6

P698

Q35033877-BF7361E6-1E59-4AF7-9099-3D6AFC792AE4

P921

Q35033877-674407D9-83D1-49B5-B901-C929262371ED

P932

Q35033877-CF4BEBE6-9968-4EB4-A927-2B2D0047F8A8

P356

P1433

Genes & Development

P1476

mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry

@en

P2093

Joseph Avruch

http://www.w3.org/2001/XMLSchema#string

Joseph Rapley

http://www.w3.org/2001/XMLSchema#string

M Fatih Yanik

http://www.w3.org/2001/XMLSchema#string

Matthew Angel

http://www.w3.org/2001/XMLSchema#string

Michael D Blower

http://www.w3.org/2001/XMLSchema#string

Ning Dai

http://www.w3.org/2001/XMLSchema#string

P2860

Innate immune suppression enables frequent transfection with RNA encoding reprogramming proteins

A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development

Identification and characterization of a novel cell cycle-regulated internal ribosome entry site

ZBP1 recognition of beta-actin zipcode induces RNA looping

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells

Sequential dimerization of human zipcode-binding protein IMP1 on RNA: a cooperative mechanism providing RNP stability

Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice

Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP

The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

P304

1159-1172

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1101/GAD.2042311

http://www.w3.org/2001/XMLSchema#string

P433

11

http://www.w3.org/2001/XMLSchema#string

P478

25

http://www.w3.org/2001/XMLSchema#string

P577

2011-05-16T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51130595

http://www.w3.org/2001/XMLSchema#string

P698

21576258

http://www.w3.org/2001/XMLSchema#string

P921

phosphorylation

P932

3110954

http://www.w3.org/2001/XMLSchema#string