Noncanonical TGFβ signaling contributes to aortic aneurysm progression in Marfan syndrome mice. - Wikidata - wikimedia - TriplyDB

Noncanonical TGFβ signaling contributes to aortic aneurysm progression in Marfan syndrome mice.

Noncanonical TGFβ signaling contributes to aortic aneurysm progression in Marfan syndrome mice.

http://www.wikidata.org/entity/Q35034373

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Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development Androgen receptor (AR) in cardiovascular diseases Mitral valve disease--morphology and mechanisms.Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway Vascular complications in autosomal dominant polycystic kidney disease Medical treatment of aortic aneurysms in Marfan syndrome and other heritable conditions Educational paper. Connective tissue disorders with vascular involvement: from gene to therapy Myofibroblasts: trust your heart and let fate decide.Sustained induction of collagen synthesis by TGF-β requires regulated intramembrane proteolysis of CREB3L1 Marfan syndrome: An eyesight of syndrome TGFβ signalling in context The identification of pathway markers in intracranial aneurysm using genome-wide association data from two different populations Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia New Insights Into Aortic Diseases: A Report From the Third International Meeting on Aortic Diseases (IMAD3)High prevalence of eosinophilic esophagitis in patients with inherited connective tissue disorders.BMP signaling modulation attenuates cerebral arteriovenous malformation formation in a vertebrate model Losartan inhibits endothelial-to-mesenchymal transformation in mitral valve endothelial cells by blocking transforming growth factor-β-induced phosphorylation of ERK.Possible extracardiac predictors of aortic dissection in Marfan syndrome.Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries.Embryonic origins of human vascular smooth muscle cells: implications for in vitro modeling and clinical application The Pathogenic Transforming Growth Factor-β Overdrive Hypothesis in Aortic Aneurysms and Dissections: A Mirage?Non-coding RNA Contribution to Thoracic and Abdominal Aortic Aneurysm Disease Development and Progression.Altered tissue behavior of a non-aneurysmal descending thoracic aorta in the mouse model of Marfan syndrome.The genetic basis of aortic aneurysm Losartan slows pancreatic tumor progression and extends survival of SPARC-null mice by abrogating aberrant TGFβ activation.MMP-2 regulates Erk1/2 phosphorylation and aortic dilatation in Marfan syndrome TGFBR1 mutations associated with Loeys-Dietz syndrome are inactivating.Inflammation aggravates disease severity in Marfan syndrome patients.Analysis of extracellular superoxide dismutase and Akt in ascending aortic aneurysm with tricuspid or bicuspid aortic valve BAMBI regulates angiogenesis and endothelial homeostasis through modulation of alternative TGFβ signaling.mTOR inhibition rescues osteopenia in mice with systemic sclerosis.The SMAD-binding domain of SKI: a hotspot for de novo mutations causing Shprintzen-Goldberg syndrome.Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism.Identification of Hic-5 as a novel scaffold for the MKK4/p54 JNK pathway in the development of abdominal aortic aneurysms.Smooth muscle LDL receptor-related protein-1 deletion induces aortic insufficiency and promotes vascular cardiomyopathy in mice Hypertension overrides the protective effect of female hormones on the development of aortic aneurysm secondary to Alk5 deficiency via ERK activation.Dimorphic effects of transforming growth factor-β signaling during aortic aneurysm progression in mice suggest a combinatorial therapy for Marfan syndrome Connective tissue disorders and cardiovascular complications: the indomitable role of transforming growth factor-beta signaling SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model.Genome-wide association study identifies a susceptibility locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 at 15q21.1.

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P2860

Noncanonical TGFβ signaling contributes to aortic aneurysm progression in Marfan syndrome mice.

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Noncanonical TGFβ signaling co ...... ssion in Marfan syndrome mice.

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Noncanonical TGFβ signaling co ...... ssion in Marfan syndrome mice.

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P2860

Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome

Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein

Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome

RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2

Aneurysm syndromes caused by mutations in the TGF-beta receptor

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA

Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

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