Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway
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2015 Clinical trials update in sickle cell anemiaRare and low-frequency coding variants in CXCR2 and other genes are associated with hematological traitsEvidence for a novel antioxidant function and isoform-specific regulation of the human p66Shc gene.Monomethylfumarate induces γ-globin expression and fetal hemoglobin production in cultured human retinal pigment epithelial (RPE) and erythroid cells, and in intact retina.Comparison of DNA methylation profiles in human fetal and adult red blood cell progenitors.A conserved antioxidant response element (ARE) in the promoter of human carbonyl reductase 3 (CBR3) mediates induction by the master redox switch Nrf2Phase 1 Study of a Sulforaphane-Containing Broccoli Sprout Homogenate for Sickle Cell DiseaseSimvastatin and t-butylhydroquinone suppress KLF1 and BCL11A gene expression and additively increase fetal hemoglobin in primary human erythroid cellsNovel hematopoietic target genes in the NRF2-mediated transcriptional pathway.Cell signaling pathways involved in drug-mediated fetal hemoglobin induction: Strategies to treat sickle cell diseaseTranscriptional mechanisms underlying hemoglobin synthesis.Gene Profiles in a Smoke-Induced COPD Mouse Lung Model Following Treatment with Mesenchymal Stem Cells.Ex-vivo expansion of red blood cells: how real for transfusion in humans?Alternative options for DNA-based experimental therapy of β-thalassemia.Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders.The roles of NRF2 in modulating cellular iron homeostasis.Gamma reactivation using the spongy effect of KLF1-binding site sequence: an approach in gene therapy for beta-thalassemia.Proteasome inhibition induces both antioxidant and hb f responses in sickle cell disease via the nrf2 pathway.Piceatannol: a potential futuristic natural stilbene as fetal haemoglobin inducer.Induction of carbonyl reductase 1 (CBR1) expression in human lung tissues and lung cancer cells by the cigarette smoke constituent benzo[a]pyreneNRF2 mediates γ-globin gene regulation and fetal hemoglobin induction in human erythroid progenitors.Combining gene therapy and fetal hemoglobin induction for treatment of β-thalassemia.Loss of NRF2 function exacerbates the pathophysiology of sickle cell disease in a transgenic mouse model.Oral Monomethyl Fumarate Therapy Ameliorates Retinopathy in a Humanized Mouse Model of Sickle Cell Disease.Dimethyl fumarate increases fetal hemoglobin, provides heme detoxification, and corrects anemia in sickle cell disease.Development of phenotypic screening assays for γ-globin induction using primary human bone marrow day 7 erythroid progenitor cells.Activation of STAT3 stimulates AHSP expression in K562 cells.Control of Oxidative Stress and Inflammation in Sickle Cell Disease with the Nrf2 Activator Dimethyl Fumarate.Emerging Regulatory Role of Nrf2 in Iron, Heme, and Hemoglobin Metabolism in Physiology and Disease
P2860
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P2860
Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway
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2011 nî lūn-bûn
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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2011 թվականի ապրիլին հրատարակված գիտական հոդված
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2011年の論文
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年學術文章
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name
Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway
@ast
Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway
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type
label
Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway
@ast
Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway
@en
prefLabel
Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway
@ast
Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway
@en
P2860
P1433
P1476
Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway
@en
P2093
Christopher H Lowrey
Elizabeth R Macari
P2860
P304
P356
10.1182/BLOOD-2010-10-314096
P407
P577
2011-04-04T00:00:00Z