Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury - Wikidata - wikimedia - TriplyDB

Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury

Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury

http://www.wikidata.org/entity/Q35047279

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Function, structure and therapeutic potential of complement C5a receptors The complement system and adverse pregnancy outcomes Complement inhibition promotes endogenous neurogenesis and sustained anti-inflammatory neuroprotection following reperfused stroke Neutrophil Depletion Attenuates Placental Ischemia-Induced Hypertension in the Rat C3a receptor antagonist ameliorates inflammatory and fibrotic signals in type 2 diabetic nephropathy by suppressing the activation of TGF-β/smad3 and IKBα pathway Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection.Role of the complement components C5 and C3a in a mouse model of myocardial ischemia and reperfusion injury.Differential effects of complement activation products c3a and c5a on cardiovascular function in hypertensive pregnant rats.Downsizing a human inflammatory protein to a small molecule with equal potency and functionality.Elimination of C5aR prevents intestinal mucosal damage and attenuates neutrophil infiltration in local and remote organs.New insights of an old defense system: structure, function, and clinical relevance of the complement system.Increased Susceptibility of Humanized NSG Mice to Panton-Valentine Leukocidin and Staphylococcus aureus Skin Infection.Targeted disruption of the gene encoding the murine small subunit of carboxypeptidase N (CPN1) causes susceptibility to C5a anaphylatoxin-mediated shock.Novel C5a regulators in inflammatory disease.C3a and C5a promote renal ischemia-reperfusion injury.The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization.Neuroprotection in stroke by complement inhibition and immunoglobulin therapy.C3a receptor deficiency accelerates the onset of renal injury in the MRL/lpr mouse.Association of immune and metabolic receptors C5aR and C5L2 with adiposity in women.Role of complement and perspectives for intervention in ischemia-reperfusion damage.Complement activation in the injured central nervous system: another dual-edged sword?Tumor necrosis-initiated complement activation stimulates proliferation of medulloblastoma cells.From apelin to exercise: emerging therapies for management of hypertension in pregnancy.Improved yield and functional parameters of rat pancreas islets isolated under intramuscular anesthesia.A Commentary On: "NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer's Disease". A cautionary note regarding C3aR.Complement anaphylatoxins C3a and C5a induce a failing regenerative program in cardiac resident cells. Evidence of a role for cardiac resident stem cells other than cardiomyocyte renewal.Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a C3a receptor modulation of granulocyte infiltration after murine focal cerebral ischemia is reperfusion dependent.The Complement System and Preeclampsia.Beneficial effects of Houttuynia cordata polysaccharides on "two-hit" acute lung injury and endotoxic fever in rats associated with anti-complementary activities.C3a triggers formation of sub-retinal pigment epithelium deposits via the ubiquitin proteasome pathway.CD177-mediated nanoparticle targeting of human and mouse neutrophils LPS preconditioning ameliorates intestinal injury in a rat model of hemorrhagic shock Internalization of staphylococcal leukotoxins that bind and divert the C5a receptor is required for intracellular Ca2+mobilization by human neutrophils

P2860

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P2860

Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury

http://www.wikidata.org/entity/Q35047279

description

2004 nî lūn-bûn

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2004 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2004 թվականի մայիսին հրատարակված գիտական հոդված

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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Comparative anti-inflammatory ...... l ischaemia/reperfusion injury

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British Journal of Pharmacology

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Comparative anti-inflammatory ...... l ischaemia/reperfusion injury

@en

P2093

Ian Shiels

http://www.w3.org/2001/XMLSchema#string

Lavinia M Proctor

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Stephen M Taylor

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Thiruma V Arumugam

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P2860

Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models

Hepatocellular oxidant stress following intestinal ischemia-reperfusion injury

Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist

A new small molecule C5a receptor antagonist inhibits the reverse-passive Arthus reaction and endotoxic shock in rats

Selection of a C5a receptor antagonist from phage libraries attenuating the inflammatory response in immune complex disease and ischemia/reperfusion injury.

Role of complement activation and mast cell degranulation in the pathogenesis of rapid intestinal ischemia/reperfusion injury in rats.

Inhibition of complement C5 reduces local and remote organ injury after intestinal ischemia/reperfusion in the rat.

Is the gut responsible for multiple organ failure?

Pathophysiology of ischaemia-reperfusion injury.

Response-selective C5a agonists: differential effects on neutropenia and hypotension in the rat.

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10.1038/SJ.BJP.0705819

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4

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142

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David P. Fairlie

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8547685

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15159277

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reperfusion injury

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1575041

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