DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination. - Wikidata - wikimedia - TriplyDB

DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination.

DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination.

http://www.wikidata.org/entity/Q35048728

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The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1 SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions The multifaceted role of lysine acetylation in cancer: prognostic biomarker and therapeutic target Expanding the ubiquitin code through post-translational modification Epigenetic inheritance and the missing heritability Expanding proteostasis by membrane trafficking networks Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancer An insight into the various regulatory mechanisms modulating human DNA methyltransferase 1 stability and function Structural Insight into Coordinated Recognition of Trimethylated Histone H3 Lysine 9 (H3K9me3) by the Plant Homeodomain (PHD) and Tandem Tudor Domain (TTD) of UHRF1 (Ubiquitin-like, Containing PHD and RING Finger Domains, 1) Protein Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein Modulation of the p53/MDM2 interplay by HAUSP inhibitors The mitochondrial side of epigenetics The role of aberrant proteolysis in lymphomagenesis Crystal Structure of USP7 Ubiquitin-like Domains with an ICP0 Peptide Reveals a Novel Mechanism Used by Viral and Cellular Proteins to Target USP7 Phenotypic switching induced by damaged matrix is associated with DNA methyltransferase 3A (DNMT3A) activity and nuclear localization in smooth muscle cells (SMC)Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1 USP7 is a SUMO deubiquitinase essential for DNA replication PI3K/AKT/mTOR Signaling Mediates Valproic Acid-Induced Neuronal Differentiation of Neural Stem Cells through Epigenetic Modifications.Poly(ADP-ribose) polymerase 1 (PARP1) associates with E3 ubiquitin-protein ligase UHRF1 and modulates UHRF1 biological functions Microarray analysis uncovers a role for Tip60 in nervous system function and general metabolism PKC isoforms interact with and phosphorylate DNMT1 Sin3a-associated Hdac1 and Hdac2 are essential for hematopoietic stem cell homeostasis and contribute differentially to hematopoiesis.A reciprocal role of prostate cancer on stromal DNA damage.Inhibition of DNA methyltransferase activity and expression by treatment with the pan-deacetylase inhibitor panobinostat in hepatocellular carcinoma cell lines.RGS6 suppresses Ras-induced cellular transformation by facilitating Tip60-mediated Dnmt1 degradation and promoting apoptosis.Ginsenoside Rg3 inhibits melanoma cell proliferation through down-regulation of histone deacetylase 3 (HDAC3) and increase of p53 acetylation.Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos Regulation of mammalian DNA methyltransferases: a route to new mechanisms.DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation.Cross-talk between phospho-STAT3 and PLCγ1 plays a critical role in colorectal tumorigenesis.H3K9 methyltransferase G9a negatively regulates UHRF1 transcription during leukemia cell differentiation Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation.An integrative pan-cancer-wide analysis of epigenetic enzymes reveals universal patterns of epigenomic deregulation in cancer Histone/protein deacetylases and T-cell immune responses Changing the ubiquitin landscape during viral manipulation of the DNA damage response.M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability.Basic concepts of epigenetics: impact of environmental signals on gene expression.

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P2860

DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination.

http://www.wikidata.org/entity/Q35048728

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

DNMT1 stability is regulated b ...... ylation-driven ubiquitination.

@ast

DNMT1 stability is regulated b ...... ylation-driven ubiquitination.

@en

type

label

DNMT1 stability is regulated b ...... ylation-driven ubiquitination.

@ast

DNMT1 stability is regulated b ...... ylation-driven ubiquitination.

@en

prefLabel

DNMT1 stability is regulated b ...... ylation-driven ubiquitination.

@ast

DNMT1 stability is regulated b ...... ylation-driven ubiquitination.

@en

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SCISIGNAL.2001462

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Science Signaling

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DNMT1 stability is regulated b ...... ylation-driven ubiquitination.

@en

P2093

David Sedwick

http://www.w3.org/2001/XMLSchema#string

Hung-Ying Kao

http://www.w3.org/2001/XMLSchema#string

Jing Song

http://www.w3.org/2001/XMLSchema#string

Joseph Willis

http://www.w3.org/2001/XMLSchema#string

Kishore Guda

http://www.w3.org/2001/XMLSchema#string

Sanford D Markowitz

http://www.w3.org/2001/XMLSchema#string

Shuming Yang

http://www.w3.org/2001/XMLSchema#string

Yan Xu

http://www.w3.org/2001/XMLSchema#string

Yiqing Zhao

http://www.w3.org/2001/XMLSchema#string

Yong Wang

http://www.w3.org/2001/XMLSchema#string

P2860

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

The interaction of the SRA domain of ICBP90 with a novel domain of DNMT1 is involved in the regulation of VEGF gene expression

ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation

FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP

UHRF1 plays a role in maintaining DNA methylation in mammalian cells

Np95 is a histone-binding protein endowed with ubiquitin ligase activity

Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T

USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin

Lysine acetylation targets protein complexes and co-regulates major cellular functions

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ra80

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10.1126/SCISIGNAL.2001462

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146

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3

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47661131

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21045206

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protein ubiquitination

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3116231

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