UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases. - Wikidata - wikimedia - TriplyDB

UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases.

UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases.

http://www.wikidata.org/entity/Q35059350

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Autoimmune diseases - connecting risk alleles with molecular traits of the immune system.Mechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3 Advances in lupus genetics Network biology concepts in complex disease comorbidities Generation and differentiation of induced pluripotent stem cells reveal ankylosing spondylitis risk gene expression in bone progenitors Mapping eQTLs with RNA-seq reveals novel susceptibility genes, non-coding RNAs and alternative-splicing events in systemic lupus erythematosus Genetics of Lupus Nephritis: Clinical Implications.Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis.The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex.The effect of ethnicity and genetic ancestry on the epidemiology, clinical features and outcome of systemic lupus erythematosus.Linear ubiquitin chains: enzymes, mechanisms and biology Intracellular B Lymphocyte Signalling and the Regulation of Humoral Immunity and Autoimmunity.The Atypical Ubiquitin E2 Conjugase UBE2L3 Is an Indirect Caspase-1 Target and Controls IL-1β Secretion by Inflammasomes.A cis-eQTL genetic variant of the cancer-testis gene CCDC116 is associated with risk of multiple cancers.Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups.Profiling RNA-Seq at multiple resolutions markedly increases the number of causal eQTLs in autoimmune disease.Ubiquitin conjugating enzyme E2 L3 promoted tumor growth of NSCLC through accelerating p27kip1 ubiquitination and degradation.The Role of the Transcription Factor Ets1 in Lupus and Other Autoimmune Diseases.Abnormal B-cell development in Systemic Lupus Erythematosus: what the genetics tell us.Updates in Lupus Genetics.Internally tagged ubiquitin: a tool to identify linear polyubiquitin-modified proteins by mass spectrometry.Determinants of E2-ubiquitin conjugate recognition by RBR E3 ligases.Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort.Integrative Analysis Identifies Genetic Variants Associated With Autoimmune Diseases Affecting Putative MicroRNA Binding Sites.Host genetic factors affecting hepatitis B infection outcomes: Insights from genome-wide association studies Ubiquitin-Proteasome System: Promising Therapeutic Targets in Autoimmune and Neurodegenerative Diseases

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P2860

UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases.

http://www.wikidata.org/entity/Q35059350

description

2015 nî lūn-bûn

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2015 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2015年の論文

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2015年論文

@yue

2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

@zh-mo

2015年論文

@zh-tw

2015年论文

@wuu

name

UBE2L3 polymorphism amplifies ...... multiple autoimmune diseases.

@ast

UBE2L3 polymorphism amplifies ...... multiple autoimmune diseases.

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type

label

UBE2L3 polymorphism amplifies ...... multiple autoimmune diseases.

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UBE2L3 polymorphism amplifies ...... multiple autoimmune diseases.

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prefLabel

UBE2L3 polymorphism amplifies ...... multiple autoimmune diseases.

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UBE2L3 polymorphism amplifies ...... multiple autoimmune diseases.

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J.AJHG.2014.12.024

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American Journal of Human Genetics

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UBE2L3 polymorphism amplifies ...... o multiple autoimmune diseases

@en

P2093

Henning Walczak

http://www.w3.org/2001/XMLSchema#string

Patrick A Gordon

http://www.w3.org/2001/XMLSchema#string

Simon Vyse

http://www.w3.org/2001/XMLSchema#string

Timothy D Spector

http://www.w3.org/2001/XMLSchema#string

Timothy J Vyse

http://www.w3.org/2001/XMLSchema#string

P2860

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

LUBAC synthesizes linear ubiquitin chains via a thioester intermediate

OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

Linear ubiquitination prevents inflammation and regulates immune signalling

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

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221-234

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10.1016/J.AJHG.2014.12.024

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2

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96

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Sebastian Boeltz

Adrian M Shields

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2015-01-29T00:00:00Z

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271709897

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25640675

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protein ubiquitination

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4320258

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