Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis.
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Epithelial homeostasisThe legacy of Drosophila imaginal discsSterile inflammation in DrosophilaLoss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signalingImpaired Hippo signaling promotes Rho1-JNK-dependent growth.The orthologous Tbx transcription factors Omb and TBX2 induce epithelial cell migration and extrusion in vivo without involvement of matrix metalloproteinasesModeling tumor invasion and metastasis in DrosophilaBTB-Zinc Finger Oncogenes Are Required for Ras and Notch-Driven Tumorigenesis in Drosophila.Cooperation of the BTB-Zinc finger protein, Abrupt, with cytoskeletal regulators in Drosophila epithelial tumorigenesis.Annexin A2 silencing induces G2 arrest of non-small cell lung cancer cells through p53-dependent and -independent mechanisms.Competition among gene regulatory networks imposes order within the eye-antennal disc of Drosophila.In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signallingConundrum, an ARHGAP18 orthologue, regulates RhoA and proliferation through interactions with Moesin.Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistancep-Hydroxylcinnamaldehyde induces the differentiation of oesophageal carcinoma cells via the cAMP-RhoA-MAPK signalling pathway.Src42A modulates tumor invasion and cell death via Ben/dUev1a-mediated JNK activation in Drosophila.Oncogenic mutations produce similar phenotypes in Drosophila tissues of diverse origins.Epithelial delamination and migration: lessons from Drosophila.Drosophila cancer models.Epithelial cell polarity, stem cells and cancer.Chromosomal instability triggers cell death via local signalling through the innate immune receptor Toll.PP6 Disruption Synergizes with Oncogenic Ras to Promote JNK-Dependent Tumor Growth and Invasion.Rho GTPases: Anti- or pro-neoplastic targets?Rho1-Wnd signaling regulates loss-of-cell polarity-induced cell invasion in Drosophila.Genetic models of apoptosis-induced proliferation decipher activation of JNK and identify a requirement of EGFR signaling for tissue regenerative responses in Drosophila.Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species.Interplay among Drosophila transcription factors Ets21c, Fos and Ftz-F1 drives JNK-mediated tumor malignancy.Death takes a holiday--non-apoptotic role for caspases in cell migration and invasion.ARHGEF12 influences the risk of glaucoma by increasing intraocular pressure.How winner cells cause the demise of loser cells: cell competition causes apoptosis of suboptimal cells: their dregs are removed by hemocytes, thus preserving tissue homeostasis.Tumor-promoting function of apoptotic caspases by an amplification loop involving ROS, macrophages and JNK in Drosophila.Drosophila actin-Capping Protein limits JNK activation by the Src proto-oncogene.Modelling Cooperative Tumorigenesis in Drosophila.Grow With the Challenge - Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy
P2860
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P2860
Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis.
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2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Identification of novel Ras-co ...... ntral driver of tumorigenesis.
@ast
Identification of novel Ras-co ...... ntral driver of tumorigenesis.
@en
type
label
Identification of novel Ras-co ...... ntral driver of tumorigenesis.
@ast
Identification of novel Ras-co ...... ntral driver of tumorigenesis.
@en
prefLabel
Identification of novel Ras-co ...... ntral driver of tumorigenesis.
@ast
Identification of novel Ras-co ...... ntral driver of tumorigenesis.
@en
P2093
P2860
P50
P1433
P1476
Identification of novel Ras-co ...... ntral driver of tumorigenesis.
@en
P2093
Anthony M Brumby
Jessica E Bolden
Karen R Goulding
Peytee Khoo
Ryan Galea
Tanja Schlosser
Toshiro Aigaki
P2860
P304
P356
10.1534/GENETICS.111.127910
P407
P577
2011-03-02T00:00:00Z