Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity.
about
Genealogy of an ancient protein family: the Sirtuins, a family of disordered membersA high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complexJNK Signaling: Regulation and Functions Based on Complex Protein-Protein PartnershipsMechanisms of intrahepatic triglyceride accumulationMitochondrial dysfunction and tissue injury by alcohol, high fat, nonalcoholic substances and pathological conditions through post-translational protein modificationsRedox regulation of SIRT1 in inflammation and cellular senescenceNew Insights for Oxidative Stress and Diabetes MellitusEmerging Roles of SIRT1 in Cancer Drug ResistanceANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradationMutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment.SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylationThe ways and means that fine tune Sirt1 activity.mIGF-1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart.Phosphoproteomics combined with quantitative 14-3-3-affinity capture identifies SIRT1 and RAI as novel regulators of cytosolic double-stranded RNA recognition pathway.WISP1: Clinical insights for a proliferative and restorative member of the CCN familyUpregulation of Unc-51-like kinase 1 by nitric oxide stabilizes SIRT1, independent of autophagy.Sorting out functions of sirtuins in cancerNutrigenomics of high fat diet induced obesity in mice suggests relationships between susceptibility to fatty liver disease and the proteasome.Ginsenoside Rb1 prevents H2O2-induced HUVEC senescence by stimulating sirtuin-1 pathway.Ubiquitinated sirtuin 1 (SIRT1) function is modulated during DNA damage-induced cell death and survival.Palmitate Inhibits SIRT1-Dependent BMAL1/CLOCK Interaction and Disrupts Circadian Gene Oscillations in Hepatocytes.Combined influence of insulin resistance, overweight/obesity, and fatty liver as risk factors for type 2 diabetes.Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization.Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells.Regeneration in the nervous system with erythropoietinSalmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy.Acetylation of HDAC1 and degradation of SIRT1 form a positive feedback loop to regulate p53 acetylation during heat-shock stress.Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction.Change in fatty liver status and 5-year risk of incident metabolic syndrome: a retrospective cohort studyWISP1 neuroprotection requires FoxO3a post-translational modulation with autoregulatory control of SIRT1Developmental programming of pediatric nonalcoholic fatty liver disease: redefining the"first hit".The REGγ proteasome regulates hepatic lipid metabolism through inhibition of autophagy.Calorie restriction and sirtuins revisitedCHFR negatively regulates SIRT1 activity upon oxidative stress.Non-alcoholic steatohepatitis and hepatocellular carcinoma: implications for lycopene intervention.Amphetamines promote mitochondrial dysfunction and DNA damage in pulmonary hypertensionA redox-resistant sirtuin-1 mutant protects against hepatic metabolic and oxidant stress.c-Jun N-terminal kinase 1/c-Jun activation of the p53/microRNA 34a/sirtuin 1 pathway contributes to apoptosis induced by deoxycholic acid in rat liver.
P2860
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P2860
Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Sirtuin 1 (SIRT1) protein degr ...... hepatic steatosis in obesity.
@ast
Sirtuin 1 (SIRT1) protein degr ...... hepatic steatosis in obesity.
@en
type
label
Sirtuin 1 (SIRT1) protein degr ...... hepatic steatosis in obesity.
@ast
Sirtuin 1 (SIRT1) protein degr ...... hepatic steatosis in obesity.
@en
prefLabel
Sirtuin 1 (SIRT1) protein degr ...... hepatic steatosis in obesity.
@ast
Sirtuin 1 (SIRT1) protein degr ...... hepatic steatosis in obesity.
@en
P2093
P2860
P356
P1476
Sirtuin 1 (SIRT1) protein degr ...... hepatic steatosis in obesity.
@en
P2093
Indu Kheterpal
Jianping Ye
Norm Kennedy
Roger J Davis
Zhanguo Gao
P2860
P304
22227-22234
P356
10.1074/JBC.M111.228874
P407
P577
2011-05-03T00:00:00Z