The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function
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MECHANISMS IN ENDOCRINOLOGY: Alternative splicing: the new frontier in diabetes researchFrom genetics of inflammatory bowel disease towards mechanistic insightsGenetic and epigenetic variation in the lineage specification of regulatory T cells.Tyrosine 201 of the cytoplasmic tail of CTLA-4 critically affects T regulatory cell suppressive function.Opposing effects of CTLA4 insufficiency on regulatory versus conventional T cells in autoimmunity converge on effector memory in target tissue.64Cu-DOTA-anti-CTLA-4 mAb enabled PET visualization of CTLA-4 on the T-cell infiltrating tumor tissuesThe B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetesThe soluble isoform of CTLA-4 as a regulator of T-cell responses.Overexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunityAssociation of Cytotoxic T-Lymphocyte Antigen 4 (CTLA4) and Thyroglobulin (TG) Genetic Variants with Autoimmune Hypothyroidism.Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease.Interleukin 2 Topical Cream for Treatment of Diabetic Foot Ulcer: Experiment ProtocolConstruction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression.Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family.Comparative genetics: synergizing human and NOD mouse studies for identifying genetic causation of type 1 diabetesFrom markers to molecular mechanisms: type 1 diabetes in the post-GWAS era.Modulation of Phenotype and Function of Human CD4+CD25+ T Regulatory Lymphocytes Mediated by cAMP-Elevating AgentsGene targeting in NOD mouse embryos using zinc-finger nucleases.Immune checkpoints in central nervous system autoimmunity.Autologous regulatory T cells for the treatment of type 1 diabetes.Genetic analysis of type 1 diabetes: embryonic stem cells as new tools to unlock biological mechanisms in type 1 diabetes.Treg and CTLA-4: two intertwining pathways to immune tolerance.Advances in siRNA delivery to T-cells: potential clinical applications for inflammatory disease, cancer and infection.Alternative Splicing in CKD.Restoring Regulatory T Cells in Type 1 Diabetes.Association between cytotoxic T-lymphocyte associated protein 4 gene +49 A/G polymorphism and chronic infection with hepatitis B virus: a meta-analysis.Disease-specific biases in alternative splicing and tissue-specific dysregulation revealed by multitissue profiling of lymphocyte gene expression in type 1 diabetes.Indoleamine 2,3 dioxygenase contributes to transferable tolerance in rat red blood cell inducible model of experimental autoimmune haemolytic anaemia.In vitro Treg expansion favors the full-length splicing isoform of CTLA4.CD4⁺ CD45RA⁻ FoxP3high activated regulatory T cells are functionally impaired and related to residual insulin-secreting capacity in patients with type 1 diabetes.The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future.Association analysis of PTPN22, CTLA4 and IFIH1 genes with type 1 diabetes in Colombian families.Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) in isolated vitiligo: a genotype-phenotype correlation
P2860
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P2860
The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function
description
2011 nî lūn-bûn
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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
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name
The soluble CTLA-4 splice vari ...... tes regulatory T-cell function
@ast
The soluble CTLA-4 splice vari ...... tes regulatory T-cell function
@en
type
label
The soluble CTLA-4 splice vari ...... tes regulatory T-cell function
@ast
The soluble CTLA-4 splice vari ...... tes regulatory T-cell function
@en
prefLabel
The soluble CTLA-4 splice vari ...... tes regulatory T-cell function
@ast
The soluble CTLA-4 splice vari ...... tes regulatory T-cell function
@en
P2093
P2860
P356
P1433
P1476
The soluble CTLA-4 splice vari ...... tes regulatory T-cell function
@en
P2093
Alma Zernecke
Daniel B Rainbow
Kay D Gerold
Linda S Wicker
P2860
P304
P356
10.2337/DB11-0130
P407
P577
2011-05-20T00:00:00Z