Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to leishmania donovani infection but develop severe liver immunopathology - Wikidata - wikimedia - TriplyDB

Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to leishmania donovani infection but develop severe liver immunopathology

Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to leishmania donovani infection but develop severe liver immunopathology

http://www.wikidata.org/entity/Q35070810

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Immune response and immunopathology during toxoplasmosis Interleukin-27: balancing protective and pathological immunity Protection and pathology during parasite infection: IL-10 strikes the balance Biology of IL-27 and its role in the host immunity against Mycobacterium tuberculosis IL-27 receptor signalling restricts the formation of pathogenic, terminally differentiated Th1 cells during malaria infection by repressing IL-12 dependent signals Regulation of immunity during visceral Leishmania infection Combined Immune Therapy for the Treatment of Visceral Leishmaniasis Timed action of IL-27 protects from immunopathology while preserving defense in influenza Immune regulation during chronic visceral leishmaniasis.Molecular pathways in the induction of interleukin-27-driven regulatory type 1 cells.Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease AAV2-mediated subretinal gene transfer of mIL-27p28 attenuates experimental autoimmune uveoretinitis in mice gp130 at the nexus of inflammation, autoimmunity, and cancer.IL-10-producing Th1 cells and disease progression are regulated by distinct CD11c⁺ cell populations during visceral leishmaniasis Suppression of TNF-α and IL-1 signaling identifies a mechanism of homeostatic regulation of macrophages by IL-27 IL-27-induced modulation of autoimmunity and its therapeutic potential.The WSX-1 pathway restrains intestinal T-cell immunity IL-27 is required for shaping the magnitude, affinity distribution, and memory of T cells responding to subunit immunization.Balancing immunity and pathology in visceral leishmaniasis.Responses to Leishmania donovani in mice deficient in interleukin-12 (IL-12), IL-12/IL-23, or IL-18 The IL-27 receptor has biphasic effects in crescentic glomerulonephritis mediated through Th1 responses.IL-27 and IL-21 are associated with T cell IL-10 responses in human visceral leishmaniasis.Role and therapeutic value of dendritic cells in central nervous system autoimmunity.Granzyme-mediated regulation of host defense in the liver in experimental Leishmania donovani infection.A role for IL-27 in limiting T regulatory cell populations.Transcriptional suppression of IL-27 production by Mycobacterium tuberculosis-activated p38 MAPK via inhibition of AP-1 binding.Type 1 regulatory T cells (Tr1) in autoimmunity Induction of regulatory Tr1 cells and inhibition of T(H)17 cells by IL-27.IL-27 Signaling Is Crucial for Survival of Mice Infected with African Trypanosomes via Preventing Lethal Effects of CD4+ T Cells and IFN-γ.T helper1/t helper2 cells and resistance/susceptibility to leishmania infection: is this paradigm still relevant?Elevated circulating interleukin-27 in patients with coronary artery disease is associated with dendritic cells, oxidized low-density lipoprotein, and severity of coronary artery stenosis.Interleukin-12 and tuberculosis: an old story revisited The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.Prostaglandin E2 inhibits Tr1 cell differentiation through suppression of c-Maf Temporal regulation of interleukin-12p70 (IL-12p70) and IL-12-related cytokines in splenic dendritic cell subsets during Leishmania donovani infection.IL27: its roles in the induction and inhibition of inflammation.Accelerated control of visceral Leishmania donovani infection in interleukin-6-deficient mice.Regulatory actions of Toll-like receptor 2 (TLR2) and TLR4 in Leishmania donovani infection in the liver.IL-27 Induced by Select Candida spp. via TLR7/NOD2 Signaling and IFN-β Production Inhibits Fungal Clearance.Negative regulation of Th17 responses

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Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to leishmania donovani infection but develop severe liver immunopathology

http://www.wikidata.org/entity/Q35070810

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2006 nî lūn-bûn

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2006年の論文

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Interleukin-27R (WSX-1/T-cell ...... p severe liver immunopathology

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AJPATH.2006.050013

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The American Journal of Pathology

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Interleukin-27R (WSX-1/T-cell ...... p severe liver immunopathology

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Abhay R Satoskar

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Anjali A Satoskar

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Christopher Hunter

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Frederic J de Sauvage

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Joseph Barbi

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Kimberly M Roth

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Lucia E Rosas

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Tracy L Keiser

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Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment

Expression of IL-27 in human Th1-associated granulomatous diseases

WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27

Cloning and characterization of a novel class I cytokine receptor

Leishmania donovani-reactive Th1- and Th2-like T-cell clones from individuals who have recovered from visceral leishmaniasis

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

Gp130 and the interleukin-6 family of cytokines

Development of Th1-type immune responses requires the type I cytokine receptor TCCR

Leishmania species: models of intracellular parasitism.

Disruption of the murine interleukin-4 gene inhibits disease progression during Leishmania mexicana infection but does not increase control of Leishmania donovani infection

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158-169

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16400019

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1592683

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