The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells
about
SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stressMitochondrial Quality Control and Muscle Mass MaintenanceGlucose stimulation induces dynamic change of mitochondrial morphology to promote insulin secretion in the insulinoma cell line INS-1EMitochondrial regulation of β-cell function: maintaining the momentum for insulin releaseThe OPA1-dependent mitochondrial cristae remodeling pathway controls atrophic, apoptotic, and ischemic tissue damageMitochondrial division and fusion in metabolismLoss of OPA1 disturbs cellular calcium homeostasis and sensitizes for excitotoxicity.Multiplex micro-respiratory measurements of Arabidopsis tissues.Role of Mitochondria in Alcoholic Liver DiseaseA Mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver.Mitochondrial morphological features are associated with fission and fusion eventsMitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage.Dynamin-mediated Nephrin phosphorylation regulates glucose-stimulated insulin release in pancreatic beta cells.Diabetes reduces β-cell mitochondria and induces distinct morphological abnormalities, which are reproducible by high glucose in vitro with attendant dysfunctionOPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instabilityMitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology.Parasitic nematode-induced modulation of body weight and associated metabolic dysfunction in mouse models of obesity.p32 protein levels are integral to mitochondrial and endoplasmic reticulum morphology, cell metabolism and survival.Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development.Rhein protects pancreatic β-cells from dynamin-related protein-1-mediated mitochondrial fission and cell apoptosis under hyperglycemiaInsulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 signaling pathwayMitochondrial energy metabolism and redox signaling in brain aging and neurodegenerationInhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes.Mitochondrial dynamics in neurodegeneration.Mitochondrial dynamics and morphology in beta-cells.Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure.New roles for OMA1 metalloprotease: From mitochondrial proteostasis to metabolic homeostasis.Mitochondrial dynamic changes in health and genetic diseases.Mitochondrial dynamics, mitophagy and cardiovascular disease.Mitochondrial network regulation and its potential interference with inflammatory signals in pancreatic beta cells.Role of Mitochondrial Dysfunction in Hypertension and Obesity.Mitochondrial morphology and dynamics in hepatocytes from normal and ethanol-fed rats.Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming.Chronic Exposure to Proline Causes Aminoacidotoxicity and Impaired Beta-Cell Function: Studies In Vitro.Mitochondrial dynamics: functional link with apoptosis.Mitochondrial dysfunction in an Opa1(Q285STOP) mouse model of dominant optic atrophy results from Opa1 haploinsufficiency.IL-1β hampers glucose-stimulated insulin secretion in Cohen diabetic rat islets through mitochondrial cytochrome c oxidase inhibition by nitric oxide.The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure.OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance.The emerging role of immune dysfunction in mitochondrial diseases as a paradigm for understanding immunometabolism.
P2860
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P2860
The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The dynamin-related GTPase Opa ...... ction in pancreatic beta cells
@ast
The dynamin-related GTPase Opa ...... ction in pancreatic beta cells
@en
type
label
The dynamin-related GTPase Opa ...... ction in pancreatic beta cells
@ast
The dynamin-related GTPase Opa ...... ction in pancreatic beta cells
@en
prefLabel
The dynamin-related GTPase Opa ...... ction in pancreatic beta cells
@ast
The dynamin-related GTPase Opa ...... ction in pancreatic beta cells
@en
P2093
P2860
P356
P1476
The dynamin-related GTPase Opa ...... ction in pancreatic beta cells
@en
P2093
Brian M Polster
Hiromi Sesaki
Junko Wakabayashi
Mehboob A Hussain
Miho Iijima
Mikhail V Pletnikov
Nobunao Wakabayashi
Orian S Shirihai
Pascaline Clerc
Sam Sereda
P2860
P304
P356
10.1091/MBC.E10-12-0933
P577
2011-05-05T00:00:00Z