MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination. - Wikidata - wikimedia - TriplyDB

MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination.

MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination.

http://www.wikidata.org/entity/Q35084991

about

Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1 Hydrogen peroxide sensing, signaling and regulation of transcription factors Small molecule compounds targeting the p53 pathway: are we finally making progress?Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization Dysregulation of ubiquitin ligases in cancer The pharmacodynamics of the p53-Mdm2 targeting drug Nutlin: the role of gene-switching noise High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia.An observational study on the expression levels of MDM2 and MDMX proteins, and associated effects on P53 in a series of human liposarcomas MDM2 oligomers: antagonizers of the guardian of the genome.Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis The MDM2 gene family.Regulation of the DNA damage response by ubiquitin conjugation.MAGE-A Cancer/Testis Antigens Inhibit MDM2 Ubiquitylation Function and Promote Increased Levels of MDM4 The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer.The Roles of MDM2 and MDMX Phosphorylation in Stress Signaling to p53.Casein kinase 1α regulates an MDMX intramolecular interaction to stimulate p53 binding.MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response Targeting RING domains of Mdm2-MdmX E3 complex activates apoptotic arm of the p53 pathway in leukemia/lymphoma cells The Role of p53 and MDM2 in Head and Neck Cancer.Estrogen receptor alpha (ERα/ESR1) mediates the p53-independent overexpression of MDM4/MDMX and MDM2 in human breast cancer.MDMX contains an autoinhibitory sequence element.Calpain-mediated degradation of MDMx/MDM4 contributes to HIV-induced neuronal damage.Dual function of MDM2 and MDMX toward the tumor suppressors p53 and RB.MDM4 SNP34091 (rs4245739) and its effect on breast-, colon-, lung-, and prostate cancer risk.Schedule-dependent interaction between anticancer treatments.The regulation of MDM2 oncogene and its impact on human cancers.A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression.TP53 promoter methylation in primary glioblastoma: relationship with TP53 mRNA and protein expression and mutation status.Essential Roles of E3 Ubiquitin Ligases in p53 Regulation.TP53 supports basal-like differentiation of mammary epithelial cells by preventing translocation of deltaNp63 into nucleoli.Mdm2 and MdmX partner to regulate p53.Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy.Tumour suppressors and cellular senescence.Regulation of transcriptional activators by DNA-binding domain ubiquitination.FL118 induces p53-dependent senescence in colorectal cancer cells by promoting degradation of MdmX.Mdm2 Splice isoforms regulate the p53/Mdm2/Mdm4 regulatory circuit via RING domain-mediated ubiquitination of p53 and Mdm4.Regulation of Mdm2 protein stability and the p53 response by NEDD4-1 E3 ligase.DNA-binding regulates site-specific ubiquitination of IRF-1.Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis.MDM2-MDM4 molecular interaction investigated by atomic force spectroscopy and surface plasmon resonance.

P2860

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P2860

MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination.

http://www.wikidata.org/entity/Q35084991

description

2011 nî lūn-bûn

@nan

2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի մայիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination.

@ast

MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination.

@en

type

label

MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination.

@ast

MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination.

@en

prefLabel

MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination.

@ast

MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination.

@en

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JBC.M110.213868

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Journal of Biological Chemistry

P1476

MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination.

@en

P2093

Junru Wang

http://www.w3.org/2001/XMLSchema#string

Xinjiang Wang

http://www.w3.org/2001/XMLSchema#string

Xuejun Jiang

http://www.w3.org/2001/XMLSchema#string

P2860

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX

Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase

Mdm2 promotes the rapid degradation of p53

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation.

DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms.

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23725-23734

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10.1074/JBC.M110.213868

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27

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286

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2011-05-13T00:00:00Z

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