Genetic dissection of eosinophilic esophagitis provides insight into disease pathogenesis and treatment strategies - Wikidata - wikimedia - TriplyDB

Genetic dissection of eosinophilic esophagitis provides insight into disease pathogenesis and treatment strategies

Genetic dissection of eosinophilic esophagitis provides insight into disease pathogenesis and treatment strategies

http://www.wikidata.org/entity/Q35085864

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Recent advances in understanding/managing eosinophilic esophagitis in adults Eosinophilic esophagitis The pathophysiology of eosinophilic esophagitis High prevalence of eosinophilic esophagitis in patients with inherited connective tissue disorders.Risk factors for eosinophilic esophagitis.Genetic and epigenetic underpinnings of eosinophilic esophagitis Low serum interleukin-13 levels correlate with poorer prognoses for colorectal cancer patients.Increased prevalence of eosinophilic gastrointestinal disorders in pediatric PTEN hamartoma tumor syndromes Smad3-deficient mice have reduced esophageal fibrosis and angiogenesis in a model of egg-induced eosinophilic esophagitis Analysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencing MicroRNA signature in patients with eosinophilic esophagitis, reversibility with glucocorticoids, and assessment as disease biomarkers.Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis The Greater Cincinnati Pediatric Clinic Repository: A Novel Framework for Childhood Asthma and Allergy Research.LRRC31 is induced by IL-13 and regulates kallikrein expression and barrier function in the esophageal epithelium.Mechanisms of Disease of Eosinophilic Esophagitis.Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases.Demethylation of the human eotaxin-3 gene promoter leads to the elevated expression of eotaxin-3.Targeting AMCase reduces esophageal eosinophilic inflammation and remodeling in a mouse model of egg induced eosinophilic esophagitis.Non-IgE-mediated gastrointestinal food allergies: distinct differences in clinical phenotype between Western countries and Japan.Eosinophilic gastroenteritis: an update.Targeting eosinophils in allergy, inflammation and beyond.Eosinophilic esophagitis: an immune-mediated esophageal disease.Recognition, assessment and management of eosinophilic oesophagitis.Emerging drugs for eosinophilic esophagitis.Recent advances in the pathophysiology and management of eosinophilic oesophagitis.An updated review on gastro-esophageal reflux in pediatrics.Assessing Early Life Factors for Eosinophilic Esophagitis: Lessons From Other Allergic Diseases.IL-13 receptor α1 differentially regulates aeroallergen-induced lung responses Calpain-14 and its association with eosinophilic esophagitis.Diagnosis and treatment of eosinophilic esophagitis in clinical practice.Eosinophilic Esophagitis: A Primary Disease of the Esophageal Mucosa.Biomechanics of esophageal function in eosinophilic esophagitis.Eosinophilic gastrointestinal diseases--clinically diverse and histopathologically confounding.Working with the US Food and Drug Administration: progress and timelines in understanding and treating patients with eosinophilic esophagitis.Pollen-food allergy syndrome is a common allergic comorbidity in adults with eosinophilic esophagitis.Serum Biomarkers for the Diagnosis of Eosinophilic Esophagitis and Eosinophilic Gastroenteritis.Pediatric Eosinophilic Esophagitis Endotypes: Are We Closer to Predicting Treatment Response?Early-life environmental exposures interact with genetic susceptibility variants in pediatric patients with eosinophilic esophagitis.Elevated IL-33 expression is associated with pediatric eosinophilic esophagitis, and exogenous IL-33 promotes eosinophilic esophagitis development in mice.Whole-exome sequencing uncovers oxidoreductases DHTKD1 and OGDHL as linkers between mitochondrial dysfunction and eosinophilic esophagitis.

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Genetic dissection of eosinophilic esophagitis provides insight into disease pathogenesis and treatment strategies

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The Journal of Allergy and Clinical Immunology

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Genetic dissection of eosinoph ...... nesis and treatment strategies

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Joseph D Sherrill

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Marc E Rothenberg

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P2860

Multiple common variants for celiac disease influencing immune gene expression

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

Newly identified genetic risk variants for celiac disease related to the immune response

Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations

Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment

T lymphocyte activation gene identification by coregulated expression on DNA microarrays

Eosinophilic esophagitis

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

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23-32; quiz 33-4

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