FERM domain phosphoinositide binding targets merlin to the membrane and is essential for its growth-suppressive function.
about
Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleusA neuronal function of the tumor suppressor protein merlinPhosphoinositides: tiny lipids with giant impact on cell regulationMolecular conformation of the full-length tumor suppressor NF2/Merlin--a small-angle neutron scattering studyChildhood neurofibromatosis type 2 (NF2) and related disorders: from bench to bedside and biologically targeted therapies.Neurofibromatosis type 2 tumor suppressor protein, NF2, induces proteasome-mediated degradation of JC virus T-antigen in human glioblastomaCellular and molecular interactions of phosphoinositides and peripheral proteinsMerlin: a tumour suppressor with functions at the cell cortex and in the nucleus.Molecular insights into NF2/Merlin tumor suppressor function.Cdc42 regulates Schwann cell radial sorting and myelin sheath folding through NF2/merlin-dependent and independent signalingSynthesis of an inositol hexakisphosphate (IP6) affinity probe to study the interactome from a colon cancer cell line.The N-cadherin cytoplasmic domain confers anchorage-independent growth and the loss of contact inhibition.Merlin sumoylation is required for its tumor suppressor activity.Loss of expression of the differentially expressed in adenocarcinoma of the lung (DAL-1) protein is associated with metastasis of non-small cell lung carcinoma cells.Inhibition of RAS activation due to a homozygous ezrin variant in patients with profound intellectual disability.Role of Phosphorylation in Moesin Interactions with PIP2-Containing Biomimetic Membranes.Protein kinase C zeta suppresses low- or high-grade colorectal cancer (CRC) phenotypes by interphase centrosome anchoring.Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2.NF2/Merlin Inactivation and Potential Therapeutic Targets in Mesothelioma.
P2860
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P2860
FERM domain phosphoinositide binding targets merlin to the membrane and is essential for its growth-suppressive function.
description
2011 nî lūn-bûn
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2011 թուականի Մարտին հրատարակուած գիտական յօդուած
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2011 թվականի մարտին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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name
FERM domain phosphoinositide b ...... s growth-suppressive function.
@ast
FERM domain phosphoinositide b ...... s growth-suppressive function.
@en
type
label
FERM domain phosphoinositide b ...... s growth-suppressive function.
@ast
FERM domain phosphoinositide b ...... s growth-suppressive function.
@en
prefLabel
FERM domain phosphoinositide b ...... s growth-suppressive function.
@ast
FERM domain phosphoinositide b ...... s growth-suppressive function.
@en
P2093
P2860
P356
P1476
FERM domain phosphoinositide b ...... s growth-suppressive function.
@en
P2093
Andrew B Herr
Deborah G Conrady
Lauren A Foster
Robert F Hennigan
Timmy Mani
Wallace Ip
P2860
P304
P356
10.1128/MCB.00609-10
P407
P577
2011-03-14T00:00:00Z