Heat shock protein 90 as a molecular target for cancer therapeutics.
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Nm23-H1 metastasis suppressor expression level influences the binding properties, stability, and function of the kinase suppressor of Ras1 (KSR1) Erk scaffold in breast carcinoma cellsThe heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferonsChaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperonesTheileria-induced constitutive IKK activation is independent of functional Hsp90Hsp60 regulation of tumor cell apoptosisUbiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligaseInteraction of pro-apoptotic protein HGTD-P with heat shock protein 90 is required for induction of mitochondrial apoptotic cascadesHeat shock protein 90: role in enterovirus 71 entry and assembly and potential target for therapyCritical regulation of TGFbeta signaling by Hsp90Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexesCombinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancerInhibition of Hsp90 acts synergistically with topoisomerase II poisons to increase the apoptotic killing of cells due to an increase in topoisomerase II mediated DNA damageMesothelioma treatment: Are we on target? A reviewTargeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseasesExtracellular Hsp90 (eHsp90) as the actual target in clinical trials: intentionally or unintentionallySmall Molecule Inhibitors to Disrupt Protein-protein Interactions of Heat Shock Protein 90 Chaperone MachineryCorresponding functional dynamics across the Hsp90 Chaperone family: insights from a multiscale analysis of MD simulationsModeling signal propagation mechanisms and ligand-based conformational dynamics of the Hsp90 molecular chaperone full-length dimerEntamoeba Encystation: New Targets to Prevent the Transmission of AmebiasisAdvances in Development of New Treatment for LeishmaniasisDirect activation of HSP90A transcription by c-Myc contributes to c-Myc-induced transformationDrugging the cancer kinome: progress and challenges in developing personalized molecular cancer therapeuticsA comparison of Hsp90alpha and Hsp90beta interactions with cochaperones and substratesProtein kinase A-dependent translocation of Hsp90 alpha impairs endothelial nitric-oxide synthase activity in high glucose and diabetesRole of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasionExtracellular Hsp90 mediates an NF-κB dependent inflammatory stromal program: implications for the prostate tumor microenvironmentThe role of checkpoint kinase 1 in sensitivity to topoisomerase I poisonsIdentification, design and bio-evaluation of novel Hsp90 inhibitors by ligand-based virtual screeningDifferential modulation of functional dynamics and allosteric interactions in the Hsp90-cochaperone complexes with p23 and Aha1: a computational study.Heat shock protein 90 inhibition: rationale and clinical potential.Antiproliferative and proapoptotic activity of GUT-70 mediated through potent inhibition of Hsp90 in mantle cell lymphomaTargeting highly expressed extracellular HSP90 in breast cancer stem cells inhibits tumor growth in vitro and in vivo.Endocytosis and sorting of ErbB2 and the site of action of cancer therapeutics trastuzumab and geldanamycinDevelopment and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells.Phase I study of BIIB028, a selective heat shock protein 90 inhibitor, in patients with refractory metastatic or locally advanced solid tumors.Scoring functions and enrichment: a case study on Hsp90.Ubiquitin domain proteins in disease.Role of the ubiquitin proteasome system in renal cell carcinoma.To fold or not to fold: modulation and consequences of Hsp90 inhibition.
P2860
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P2860
Heat shock protein 90 as a molecular target for cancer therapeutics.
description
2003 nî lūn-bûn
@nan
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Heat shock protein 90 as a molecular target for cancer therapeutics.
@ast
Heat shock protein 90 as a molecular target for cancer therapeutics.
@en
type
label
Heat shock protein 90 as a molecular target for cancer therapeutics.
@ast
Heat shock protein 90 as a molecular target for cancer therapeutics.
@en
prefLabel
Heat shock protein 90 as a molecular target for cancer therapeutics.
@ast
Heat shock protein 90 as a molecular target for cancer therapeutics.
@en
P2093
P1433
P1476
Heat shock protein 90 as a molecular target for cancer therapeutics.
@en
P2093
Jennifer S Isaacs
Len Neckers
Wanping Xu
P304
P356
10.1016/S1535-6108(03)00029-1
P577
2003-03-01T00:00:00Z