The peptidic urotensin-II receptor ligand GSK248451 possesses less intrinsic activity than the low-efficacy partial agonists SB-710411 and urantide in native mammalian tissues and recombinant cell systems
about
GSK1562590, a slowly dissociating urotensin-II receptor antagonist, exhibits prolonged pharmacodynamic activity ex vivoBacMam technology and its application to drug discovery.Viral-mediated gene delivery for cell-based assays in drug discovery.Discovery of new antagonists aimed at discriminating UII and URP-mediated biological activities: insight into UII and URP receptor activation.Therapeutic targets in hypertension: is there a place for antagonists of the most potent vasoconstrictors?Direct inotropic effects of exogenous and endogenous urotensin-II: divergent actions in failing and nonfailing human myocardium.Urotensin-II Ligands: An Overview from Peptide to Nonpeptide StructuresPharmacological applications of baculovirus-mediated protein expression in mammalian cells.Palosuran inhibits binding to primate UT receptors in cell membranes but demonstrates differential activity in intact cells and vascular tissues.Effects of urotensin II and its specific receptor antagonist urantide on rat vascular smooth muscle cells.In vitro siRNA-mediated knockdown of the UT receptor: implications of density on the efficacy of a range of UT ligands.
P2860
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P2860
The peptidic urotensin-II receptor ligand GSK248451 possesses less intrinsic activity than the low-efficacy partial agonists SB-710411 and urantide in native mammalian tissues and recombinant cell systems
description
2006 nî lūn-bûn
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2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
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2006年の論文
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2006年学术文章
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2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
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2006年學術文章
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name
The peptidic urotensin-II rece ...... s and recombinant cell systems
@ast
The peptidic urotensin-II rece ...... s and recombinant cell systems
@en
type
label
The peptidic urotensin-II rece ...... s and recombinant cell systems
@ast
The peptidic urotensin-II rece ...... s and recombinant cell systems
@en
prefLabel
The peptidic urotensin-II rece ...... s and recombinant cell systems
@ast
The peptidic urotensin-II rece ...... s and recombinant cell systems
@en
P2093
P2860
P356
P1476
The peptidic urotensin-II rece ...... s and recombinant cell systems
@en
P2093
Christopher P A Doe
David J Behm
Dulcie B Schmidt
Gerald Stankus
Girolamo Calo'
Henry M Sarau
James A Fornwald
James J Foley
Nambi V Aiyar
Parvathi Nuthulaganti
P2860
P304
P356
10.1038/SJ.BJP.0706716
P407
P577
2006-05-01T00:00:00Z