Essential functions of the unique N-terminal region of the varicella-zoster virus glycoprotein E ectodomain in viral replication and in the pathogenesis of skin infection
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The insulin degrading enzyme binding domain of varicella-zoster virus (VZV) glycoprotein E is important for cell-to-cell spread and VZV infectivity, while a glycoprotein I binding domain is essential for infection.Functions of the unique N-terminal region of glycoprotein E in the pathogenesis of varicella-zoster virus infectionInsulin degrading enzyme induces a conformational change in varicella-zoster virus gE, and enhances virus infectivity and stabilityVaricella-zoster virus glycoprotein E is a critical determinant of virulence in the SCID mouse-human model of neuropathogenesisMutagenesis of varicella-zoster virus glycoprotein I (gI) identifies a cysteine residue critical for gE/gI heterodimer formation, gI structure, and virulence in skin cells.Direct and specific binding of the UL16 tegument protein of herpes simplex virus to the cytoplasmic tail of glycoprotein E.The amino terminus of varicella-zoster virus (VZV) glycoprotein E is required for binding to insulin-degrading enzyme, a VZV receptor.Aberrant infection and persistence of varicella-zoster virus in human dorsal root ganglia in vivo in the absence of glycoprotein I.Cellular and viral factors regulate the varicella-zoster virus gE promoter during viral replication.Deletion of the first cysteine-rich region of the varicella-zoster virus glycoprotein E ectodomain abolishes the gE and gI interaction and differentially affects cell-cell spread and viral entry.Regulation of the ORF61 promoter and ORF61 functions in varicella-zoster virus replication and pathogenesisVaricella-zoster virus and herpes simplex virus 1 can infect and replicate in the same neurons whether co- or superinfected.Investigation of varicella-zoster virus neurotropism and neurovirulence using SCID mouse-human DRG xenografts.Varicella-Zoster Virus Glycoproteins: Entry, Replication, and Pathogenesis.Mutagenesis of varicella-zoster virus glycoprotein B: putative fusion loop residues are essential for viral replication, and the furin cleavage motif contributes to pathogenesis in skin tissue in vivo.Varicella zoster virus glycoprotein E-specific CD4+ T cells show evidence of recent activation and effector differentiation, consistent with frequent exposure to replicative cycle antigens in healthy immune donors.A self-excisable infectious bacterial artificial chromosome clone of varicella-zoster virus allows analysis of the essential tegument protein encoded by ORF9.Non-clinical safety assessment of single and repeated administration of gE/AS01 zoster vaccine in rabbits.Comparative preclinical evaluation of AS01 versus other Adjuvant Systems in a candidate herpes zoster glycoprotein E subunit vaccine.Mechanisms of varicella-zoster virus neuropathogenesis in human dorsal root gangliaDevelopment of recombinant varicella-zoster viruses expressing luciferase fusion proteins for live in vivo imaging in human skin and dorsal root ganglia xenografts.
P2860
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P2860
Essential functions of the unique N-terminal region of the varicella-zoster virus glycoprotein E ectodomain in viral replication and in the pathogenesis of skin infection
description
2006 nî lūn-bûn
@nan
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Essential functions of the uni ...... pathogenesis of skin infection
@ast
Essential functions of the uni ...... pathogenesis of skin infection
@en
type
label
Essential functions of the uni ...... pathogenesis of skin infection
@ast
Essential functions of the uni ...... pathogenesis of skin infection
@en
prefLabel
Essential functions of the uni ...... pathogenesis of skin infection
@ast
Essential functions of the uni ...... pathogenesis of skin infection
@en
P2093
P2860
P356
P1433
P1476
Essential functions of the uni ...... pathogenesis of skin infection
@en
P2093
Ann M Arvin
Barbara Berarducci
Marvin Sommer
Minako Ikoma
Shaye Stamatis
P2860
P304
P356
10.1128/JVI.00533-06
P407
P577
2006-10-01T00:00:00Z