Preclinical assessment of the efficacy of mycograb, a human recombinant antibody against fungal HSP90 - Wikidata - wikimedia - TriplyDB

Preclinical assessment of the efficacy of mycograb, a human recombinant antibody against fungal HSP90

Preclinical assessment of the efficacy of mycograb, a human recombinant antibody against fungal HSP90

http://www.wikidata.org/entity/Q35102525

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beta-Actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90 Nonspecific effect of Mycograb on amphotericin B MIC Optimizing Outcomes in Immunocompromised Hosts: Understanding the Role of Immunotherapy in Invasive Fungal Diseases Emerging drugs and vaccines for candidemia Human monoclonal antibody-based therapy in the treatment of invasive candidiasis Serological profiling of a Candida albicans protein microarray reveals permanent host-pathogen interplay and stage-specific responses during candidemia Active and passive immunization with rHyr1p-N protects mice against hematogenously disseminated candidiasis Antifungal Therapy: New Advances in the Understanding and Treatment of Mycosis Human recombinant antimannan immunoglobulin G1 antibody confers resistance to hematogenously disseminated candidiasis in mice.Protection by anti-beta-glucan antibodies is associated with restricted beta-1,3 glucan binding specificity and inhibition of fungal growth and adherence Decoding serological response to Candida cell wall immunome into novel diagnostic, prognostic, and therapeutic candidates for systemic candidiasis by proteomic and bioinformatic analyses.Inhibition of fungal beta-1,3-glucan synthase and cell growth by HM-1 killer toxin single-chain anti-idiotypic antibodies.Therapy of murine pulmonary aspergillosis with antibody-alliinase conjugates and alliin.Ab binding alters gene expression in Cryptococcus neoformans and directly modulates fungal metabolism.Pathogen-specific antibodies: codependent no longer Candida infections and their prevention.Vaccination with recombinant N-terminal domain of Als1p improves survival during murine disseminated candidiasis by enhancing cell-mediated, not humoral, immunity.Regulatory circuitry governing fungal development, drug resistance, and disease.Self-adjuvanting glycopeptide conjugate vaccine against disseminated candidiasis.Hybridoma passage in vitro may result in reduced ability of antimannan antibody to protect against disseminated candidiasis Dose range evaluation of Mycograb C28Y variant, a human recombinant antibody fragment to heat shock protein 90, in combination with amphotericin B-desoxycholate for treatment of murine systemic candidiasis Identification and characterisation of a novel heat shock protein 90 inhibitor ONO4140.Vaccine and monoclonal antibody that enhance mouse resistance to candidiasis Genetically recombinant antibodies: new therapeutics against candidiasis.Passive antibody therapy for infectious diseases.New concepts in antibody-mediated immunity.Antibody Peptide based antifungal immunotherapy Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics - an update.Vaccines in the treatment of invasive candidiasis.New approaches in the development of a vaccine for mucosal candidiasis: progress and challenges Fungal heat-shock proteins in human disease.Opportunistic fungi and fungal infections: the challenge of a single, general antifungal vaccine.Immunomodulatory therapy in yeast infections.Synthetic glycopeptide vaccines combining beta-mannan and peptide epitopes induce protection against candidiasis.Antibody-mediated protection through cross-reactivity introduces a fungal heresy into immunological dogma.Combination antifungals: an update.Anti-infective antibodies: a novel tool to prevent and treat nosocomial diseases.Dynamic duo takes down fungal villains.Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance Immunocompromised hosts: immunopharmacology of modern antifungals.

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P2860

Preclinical assessment of the efficacy of mycograb, a human recombinant antibody against fungal HSP90

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AAC.47.7.2208-2216.2003

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Antimicrobial Agents and Chemotherapy

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Preclinical assessment of the ...... antibody against fungal HSP90

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Carl Gregory

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Caroline Chapman

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Chris Illidge

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Gordon Rigg

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James Burnie

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Ruth C Matthews

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Tracey Carter

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P2860

Nitric oxide: physiology, pathophysiology, and pharmacology

Molecular cloning of sequences encoding the human heat-shock proteins and their expression during hyperthermia

Purification and identification of secreted oxidative stress-induced factors from vascular smooth muscle cells

Developmental changes in the expression of Leishmania chagasi gp63 and heat shock protein in a human macrophage cell line.

Geldanamycin attenuates NO-mediated dilation in human skin.

Do in vitro susceptibility data predict the microbiologic response to amphotericin B? Results of a prospective study of patients with Candida fungemia.

GHKL, an emergent ATPase/kinase superfamily.

Heat shock protein 90 catalyzes activation of the prekallikrein-kininogen complex in the absence of factor XII.

Antifungal susceptibility testing: practical aspects and current challenges.

Interaction between fluconazole and amphotericin B in mice with systemic infection due to fluconazole-susceptible or -resistant strains of Candida albicans.

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2208-2216

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10.1128/AAC.47.7.2208-2216.2003

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12821470

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