Acyl glucuronide reactivity in perspective: biological consequences.
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Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic propertiesMetabolic profiling of praziquantel enantiomers.Mycophenolate mofetil alters the antioxidant status in duodenum of rats: Implication for silymarin usage in mycophenolate mofetil-induced gastrointestinal disorders.The human UDP-glucuronosyltransferases: structural aspects and drug glucuronidation.Simultaneous quantification of mycophenolic acid and its glucuronide metabolites in human plasma by an UPLC-MS/MS assay.Effects of gender, age, diabetes mellitus and renal and hepatic impairment on tadalafil pharmacokinetics.Minimising the potential for metabolic activation in drug discovery.An enzyme-linked immunosorbent assay for detecting 3-phenoxybenzoic acid in plasma and its application in farmers and consumers.Role of biotransformation studies in minimizing metabolism-related liabilities in drug discovery.Filling and mining the reactive metabolite target protein database.Glucuronidation and covalent protein binding of benoxaprofen and flunoxaprofen in sandwich-cultured rat and human hepatocytes.CPY3A4-mediated α-hydroxyaldehyde formation in saquinavir metabolism.Metabolites in safety testing: "MIST" for the clinical pharmacologist.N-glucuronidation of drugs and other xenobiotics by human and animal UDP-glucuronosyltransferases.Managing the challenge of chemically reactive metabolites in drug development.Evaluation of the intestinal toxicity and transport of xenobiotics utilizing precision-cut slices.Clinical mycophenolic acid monitoring in liver transplant recipients.Structure, function and carcinogenicity of metabolites of methylated and non-methylated polycyclic aromatic hydrocarbons: a comprehensive review.How polymorphisms of the cytochrome P450 genes affect ibuprofen and diclofenac metabolism and toxicity.Non-cytochrome P450-mediated bioactivation and its toxicological relevance.Clinical Pharmacokinetics and Pharmacodynamics of Febuxostat.Enteric-coated mycophenolate sodium - current and future use in transplant patients.Quantitation of celecoxib and four of its metabolites in rat blood by UPLC-MS/MS clarifies their blood distribution patterns and provides more accurate pharmacokinetics profiles.Simulation of chemical metabolism for fate and hazard assessment. V. Mammalian hazard assessment.Nuclear magnetic resonance (NMR) and quantitative structure-activity relationship (QSAR) studies on the transacylation reactivity of model 1beta-O-acyl glucuronides. II: QSAR modelling of the reaction using both computational and experimental NMR paKinetic studies on the intramolecular acyl migration of beta-1-O-acyl glucuronides: application to the glucuronides of (R)- and (S)-ketoprofen, (R)- and (S)-hydroxy-ketoprofen metabolites, and tolmetin by 1H-NMR spectroscopy.Involvement of Mrp2 (Abcc2) in biliary excretion of moxifloxacin and its metabolites in the isolated perfused rat liver.Guidance on the establishment of the residue definition for dietary risk assessmentScientific Opinion on the risks for human and animal health related to the presence of modified forms of certain mycotoxins in food and feedToxicological role of an acyl glucuronide metabolite in diclofenac-induced acute liver injury in mice.Plasma concentrations of mycophenolic acid acyl glucuronide are not associated with diarrhea in renal transplant recipients.Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice.The hepatic reductase null mouse as a model for exploring hepatic conjugation of xenobiotics: application to the metabolism of diclofenac.Stereoselective Inhibition of Methotrexate Excretion by Glucuronides of Nonsteroidal Anti-inflammatory Drugs via Multidrug Resistance Proteins 2 and 4.
P2860
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P2860
Acyl glucuronide reactivity in perspective: biological consequences.
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Acyl glucuronide reactivity in perspective: biological consequences.
@ast
Acyl glucuronide reactivity in perspective: biological consequences.
@en
type
label
Acyl glucuronide reactivity in perspective: biological consequences.
@ast
Acyl glucuronide reactivity in perspective: biological consequences.
@en
prefLabel
Acyl glucuronide reactivity in perspective: biological consequences.
@ast
Acyl glucuronide reactivity in perspective: biological consequences.
@en
P1476
Acyl glucuronide reactivity in perspective: biological consequences.
@en
P2093
Mark J Bailey
Ronald G Dickinson
P304
P356
10.1016/S0009-2797(03)00020-6
P577
2003-05-01T00:00:00Z