Selection-based discovery of druglike macrocyclic peptides.
about
Recent Advances Toward the Discovery of Drug-Like Peptides De novoAdvances in the directed evolution of proteins.Peptide library approach to uncover phosphomimetic inhibitors of the BRCA1 C-terminal domainHigh-Throughput Approaches to the Development of Molecular Imaging Agents.Mechanistic studies on the substrate-tolerant lanthipeptide synthetase ProcMGeneration of a genetically encoded, photoactivatable intein for the controlled production of cyclic peptides.Ribosomal Synthesis of Macrocyclic Peptides in Vitro and in Vivo Mediated by Genetically Encoded Aminothiol Unnatural Amino AcidsConceptual and methodological advances in cell-free directed evolution.PURE mRNA display for in vitro selection of single-chain antibodies.Iminoboronate-Based Peptide Cyclization That Responds to pH, Oxidation, and Small Molecule Modulators.Expanding the amino acid repertoire of ribosomal polypeptide synthesis via the artificial division of codon boxes.Conformational Restriction of Peptides Using Dithiol Bis-AlkylationPreparation of Semisynthetic Peptides Macrocycles Using Split Inteins.A RaPID way to discover nonstandard macrocyclic peptide modulators of drug targets.Highly Constrained Bicyclic Scaffolds for the Discovery of Protease-Stable Peptides via mRNA Display.Linker-free incorporation of carbohydrates into in vitro displayed macrocyclic peptides.Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants.Beyond cyclosporine A: conformation-dependent passive membrane permeabilities of cyclic peptide natural products.New Modalities for Challenging Targets in Drug Discovery.Systematic Targeting of Protein-Protein InteractionsDirected evolution of anti-HER2 DARPins by SNAP display reveals stability/function trade-offs in the selection processDiscovery and optimization of peptide macrocycles.Macrocyclic peptide inhibitors for the protein-protein interaction of Zaire Ebola virus protein 24 and karyopherin alpha 5.Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.Thioether analogues of disulfide-bridged cyclic peptides targeting death receptor 5: conformational analysis, dimerisation and consequences for receptor activation.Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein-Protein Interactions.Hydrolytic inhibition of α-chymotrypsin by 2,8,14,20-tetrakis(D-leucyl-D-valinamido)resorc[4]arenecarboxylic acid: a spectroscopic NMR and computational combined approach.An in vitro tag-and-modify protein sample generation method for single-molecule fluorescence resonance energy transfer.Logical engineering of D-arm and T-stem of tRNA that enhances d-amino acid incorporation.A reproducible and scalable procedure for preparing bacterial extracts for cell-free protein synthesis.Synthesis of the natural product descurainolide and cyclic peptides from lignin-derived aromatics.A Fluorescent Imaging Probe Based on a Macrocyclic Scaffold That Binds to Cellular EpCAM.A lanthipeptide library used to identify a protein-protein interaction inhibitor.Synthetic fermentation of β-peptide macrocycles by thiadiazole-forming ring-closing reactions.Model foldamers: applications and structures of stable macrocyclic peptides identified using in vitro selectionCell-Permeable Bicyclic Peptidyl Inhibitors against NEMO-IκB Kinase Interaction Directly from a Combinatorial Library
P2860
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P2860
Selection-based discovery of druglike macrocyclic peptides.
description
2014 nî lūn-bûn
@nan
2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Selection-based discovery of druglike macrocyclic peptides.
@ast
Selection-based discovery of druglike macrocyclic peptides.
@en
type
label
Selection-based discovery of druglike macrocyclic peptides.
@ast
Selection-based discovery of druglike macrocyclic peptides.
@en
prefLabel
Selection-based discovery of druglike macrocyclic peptides.
@ast
Selection-based discovery of druglike macrocyclic peptides.
@en
P1476
Selection-based discovery of druglike macrocyclic peptides.
@en
P2093
Hiroaki Suga
P304
P356
10.1146/ANNUREV-BIOCHEM-060713-035456
P577
2014-02-21T00:00:00Z