Notch signaling alters sensory or neuronal cell fate specification of inner ear stem cells.
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Segregating neural and mechanosensory fates in the developing ear: patterning, signaling, and transcriptional control.Stemness of the organ of Corti relates to the epigenetic status of Sox2 enhancersLGR4 and LGR5 Regulate Hair Cell Differentiation in the Sensory Epithelium of the Developing Mouse Cochlea.Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathwayPax2 contributes to inner ear patterning and optic nerve trajectoryCo-regulation of the Notch and Wnt signaling pathways promotes supporting cell proliferation and hair cell regeneration in mouse utricles.Clonal Expansion of Lgr5-Positive Cells from Mammalian Cochlea and High-Purity Generation of Sensory Hair CellsSignaling and Transcription Factors during Inner Ear Development: The Generation of Hair Cells and Otic Neurons.Wnt activation followed by Notch inhibition promotes mitotic hair cell regeneration in the postnatal mouse cochlea.DAPT mediates atoh1 expression to induce hair cell-like cells.Manipulating cell fate in the cochlea: a feasible therapy for hearing loss.The Role of Atonal Factors in Mechanosensory Cell Specification and FunctionHair cell damage recruited Lgr5-expressing cells are hair cell progenitors in neonatal mouse utricle.A simple method for purification of vestibular hair cells and non-sensory cells, and application for proteomic analysis.LMO4 functions as a negative regulator of sensory organ formation in the mammalian cochleaChemical approaches to stem cell biology and therapeuticsSound strategies for hearing restoration.Loss of osteoprotegerin expression in the inner ear causes degeneration of the cochlear nerve and sensorineural hearing loss.Sensational placodes: neurogenesis in the otic and olfactory systems.Prospects for replacement of auditory neurons by stem cells.Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma.Understanding the evolution and development of neurosensory transcription factors of the ear to enhance therapeutic translation.Filling the silent void: genetic therapies for hearing impairment.Characterization of Lgr5+ Progenitor Cell Transcriptomes after Neomycin Injury in the Neonatal Mouse CochleaThe prosensory function of Sox2 in the chicken inner ear relies on the direct regulation of Atoh1.Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells.Modulation of the Mesenchymal Stem Cell Secretome Using Computer-Controlled Bioreactors: Impact on Neuronal Cell Proliferation, Survival and Differentiation.In vivo Notch reactivation in differentiating cochlear hair cells induces Sox2 and Prox1 expression but does not disrupt hair cell maturation.Overactivation of Notch1 signaling induces ectopic hair cells in the mouse inner ear in an age-dependent manner.Development of hair cells in inner ear is associated with expression and promoter methylation of Notch-1 in postnatal mice.Wnt-responsive Lgr5-expressing stem cells are hair cell progenitors in the cochlea.Roles of sex-determining region Y-box 2 in cell pluripotency and tumor-related signaling pathways.Sox2 in the differentiation of cochlear progenitor cells.Notch signaling during cell fate determination in the inner ear.Ectopic expression of activated notch or SOX2 reveals similar and unique roles in the development of the sensory cell progenitors in the mammalian inner ear.Progression of neurogenesis in the inner ear requires inhibition of Sox2 transcription by neurogenin1 and neurod1.Combining topographical and genetic cues to promote neuronal fate specification in stem cells.Stem cell maintenance in the adult mammalian hippocampus: a matter of signal integration?Notch signaling in mammalian hair cell regeneration.Signaling in the Auditory System: Implications in Hair Cell Regeneration and Hearing Function.
P2860
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P2860
Notch signaling alters sensory or neuronal cell fate specification of inner ear stem cells.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Notch signaling alters sensory ...... ation of inner ear stem cells.
@ast
Notch signaling alters sensory ...... ation of inner ear stem cells.
@en
type
label
Notch signaling alters sensory ...... ation of inner ear stem cells.
@ast
Notch signaling alters sensory ...... ation of inner ear stem cells.
@en
prefLabel
Notch signaling alters sensory ...... ation of inner ear stem cells.
@ast
Notch signaling alters sensory ...... ation of inner ear stem cells.
@en
P2093
P2860
P1476
Notch signaling alters sensory ...... ation of inner ear stem cells.
@en
P2093
Albert S B Edge
Masato Fujioka
Sang-Jun Jeon
Shi-Chan Kim
P2860
P304
P356
10.1523/JNEUROSCI.6366-10.2011
P407
P577
2011-06-01T00:00:00Z