Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein.
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The role of APP and BACE1 trafficking in APP processing and amyloid-β generationComputational Insights into Substrate and Site Specificities, Catalytic Mechanism, and Protonation States of the Catalytic Asp Dyad of β -SecretaseCerebrospinal Aβ11-x and 17-x levels as indicators of mild cognitive impairment and patients' stratification in Alzheimer's disease.Lipid rafts and Alzheimer's disease: protein-lipid interactions and perturbation of signaling.Neuronal β-amyloid generation is independent of lipid raft association of β-secretase BACE1: analysis with a palmitoylation-deficient mutant.Novel GαS-protein signaling associated with membrane-tethered amyloid precursor protein intracellular domain.Drosophila GPI-mannosyltransferase 2 is required for GPI anchor attachment and surface expression of chaoptin.Loss of presenilin function is associated with a selective gain of APP function.Ca2+ influx through store-operated Ca2+ channels reduces Alzheimer disease β-amyloid peptide secretion.Membrane trafficking pathways in Alzheimer's disease.Phosphorylation of FE65 at threonine 579 by GSK3β stimulates amyloid precursor protein processing.Full-length cellular β-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization.TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes
P2860
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P2860
Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Loss of cleavage at β'-site co ...... of amyloid precursor protein.
@ast
Loss of cleavage at β'-site co ...... of amyloid precursor protein.
@en
type
label
Loss of cleavage at β'-site co ...... of amyloid precursor protein.
@ast
Loss of cleavage at β'-site co ...... of amyloid precursor protein.
@en
prefLabel
Loss of cleavage at β'-site co ...... of amyloid precursor protein.
@ast
Loss of cleavage at β'-site co ...... of amyloid precursor protein.
@en
P2093
P2860
P356
P1476
Loss of cleavage at β'-site co ...... of amyloid precursor protein.
@en
P2093
Arghya Barman
Gopal Thinakaran
Kulandaivelu S Vetrivel
Phuong D Nguyen
Rajeev Prabhakar
Steven L Wagner
P2860
P304
26166-26177
P356
10.1074/JBC.M111.260471
P407
P577
2011-06-03T00:00:00Z