about
Interactions between CYP3A4 and Dietary PolyphenolsUse of In Vitro and Predictive In Silico Models to Study the Inhibition of Cytochrome P4503A by StilbenesGenetic variability in CYP3A5 and its possible consequences.Development of a fluorescence-based, ultra high-throughput screening platform for nanoliter-scale cytochrome p450 microarrays.Resolution of two substrate-binding sites in an engineered cytochrome P450eryF bearing a fluorescent probe.Experimental approaches to evaluate activities of cytochromes P450 3AHeteroactivation of cytochrome P450 1A1 by teas and tea polyphenols.Automated selection of compounds with physicochemical properties to maximize bioavailability and druglikeness.Current Approaches for Investigating and Predicting Cytochrome P450 3A4-Ligand InteractionsPredicting inhibitory drug-drug interactions and evaluating drug interaction reports using inhibition constants.Luminogenic cytochrome P450 assays.Computational prediction of human drug metabolism.Measuring specificity in multi-substrate/product systems as a tool to investigate selectivity in vivo.Cytochromes P450: a structure-based summary of biotransformations using representative substrates.Modeling kinetics of subcellular disposition of chemicals.Structure-Based Inhibitor Design for Evaluation of a CYP3A4 Pharmacophore Model.Characterization of T-5 N-oxide formation as the first highly selective measure of CYP3A5 activityDirected evolution of cytochrome P450 enzymes for biocatalysis: exploiting the catalytic versatility of enzymes with relaxed substrate specificity.Imidazopyridines as selective CYP3A4 inhibitors.Effect of glutathione on homo- and heterotropic cooperativity in cytochrome P450 3A4.Effect of statins on serum vitamin D concentrations: a systematic review and meta-analysis.Classification Models for Predicting Cytochrome P450 Enzyme-Substrate Selectivity.Simultaneous evaluation of substrate-dependent CYP3A inhibition using a CYP3A probe substrates cocktail.Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance.Comparative analysis of substrate and inhibitor interactions with CYP3A4 and CYP3A5.Resolution of multiple substrate binding sites in cytochrome P450 3A4: the stoichiometry of the enzyme-substrate complexes probed by FRET and Job's titration.Kinetics of electron transfer in the complex of cytochrome P450 3A4 with the flavin domain of cytochrome P450BM-3 as evidence of functional heterogeneity of the heme protein.Mechanism of interactions of alpha-naphthoflavone with cytochrome P450 3A4 explored with an engineered enzyme bearing a fluorescent probe.Kinetics of dithionite-dependent reduction of cytochrome P450 3A4: heterogeneity of the enzyme caused by its oligomerization.Aldrin epoxidation in flathead mullet (Mugil cephalus): possible involvement of CYP1A and CYP3A.The prognostic value of differentially expressed CYP3A subfamily members for hepatocellular carcinoma.
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
In vitro and pharmacophore insights into CYP3A enzymes.
@ast
In vitro and pharmacophore insights into CYP3A enzymes.
@en
type
label
In vitro and pharmacophore insights into CYP3A enzymes.
@ast
In vitro and pharmacophore insights into CYP3A enzymes.
@en
prefLabel
In vitro and pharmacophore insights into CYP3A enzymes.
@ast
In vitro and pharmacophore insights into CYP3A enzymes.
@en
P1476
In vitro and pharmacophore insights into CYP3A enzymes.
@en
P2093
David M Stresser
J Andrew Williams
P304
P356
10.1016/S0165-6147(03)00049-X
P50
P577
2003-04-01T00:00:00Z