MAP kinase-interacting kinases--emerging targets against cancer.
about
Grifolin induces apoptosis and promotes cell cycle arrest in the A2780 human ovarian cancer cell line via inactivation of the ERK1/2 and Akt pathways.Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73.Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.Merestinib blocks Mnk kinase activity in acute myeloid leukemia progenitors and exhibits antileukemic effects in vitro and in vivo.Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemiaInhibition of Mnk enhances apoptotic activity of cytarabine in acute myeloid leukemia cellsEukaryotic translation initiation factor 4E as a novel therapeutic target in hematological malignancies and beyond.Dual abrogation of MNK and mTOR: a novel therapeutic approach for the treatment of aggressive cancers.Targeting translation: eIF4E as an emerging anticancer drug target.Inhibition of Mnk-eIF4E pathway sensitizes the efficacy to chemotherapy in anaplastic thyroid cancer.MNK Inhibition Disrupts Mesenchymal Glioma Stem Cells and Prolongs Survival in a Mouse Model of Glioblastoma.Oncogenic MNK signalling regulates the metastasis suppressor NDRG1Unveiling new chemical scaffolds as Mnk inhibitors.Synthesis and anti-neuroinflammatory activity of lactone benzoyl hydrazine and 2-nitro-1-phenyl-1h-indole derivatives as p38α MAPK inhibitors.5,7-Dihydroxy-4'-methoxyisoflavone induces apoptosis by inhibiting the ERK and Akt pathways in human osteosarcoma cells.Dynamical insights of Mnk2 kinase activation by phosphorylation to facilitate inhibitor discovery.Targeting of protein translation as a new treatment paradigm for prostate cancer.Expression of eukaryotic initiation factor 4E and 4E binding protein 1 in colorectal carcinogenesis.Novobiocin Analogues That Inhibit the MAPK Pathway.Impact of genetic variations in the MAPK signaling pathway on outcome in metastatic colorectal cancer patients treated with first-line FOLFIRI and bevacizumab: data from FIRE-3 and TRIBE trials.Dual targeting of eIF4E by blocking MNK and mTOR pathways in leukemia.Rap2b promotes proliferation, migration, and invasion of lung cancer cells.Synergistic effects of inhibiting the MNK-eIF4E and PI3K/AKT/ mTOR pathways on cell migration in MDA-MB-231 cells.Flavonoids Effects on Hepatocellular Carcinoma in Murine Models: A Systematic Review.miR-134 increases the antitumor effects of cytarabine by targeting Mnks in acute myeloid leukemia cells.Probing the Anticancer Action of Novel Ferrocene Analogues of MNK Inhibitors
P2860
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P2860
MAP kinase-interacting kinases--emerging targets against cancer.
description
2014 nî lūn-bûn
@nan
2014 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մարտին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
MAP kinase-interacting kinases--emerging targets against cancer.
@ast
MAP kinase-interacting kinases--emerging targets against cancer.
@en
type
label
MAP kinase-interacting kinases--emerging targets against cancer.
@ast
MAP kinase-interacting kinases--emerging targets against cancer.
@en
prefLabel
MAP kinase-interacting kinases--emerging targets against cancer.
@ast
MAP kinase-interacting kinases--emerging targets against cancer.
@en
P2093
P50
P1476
MAP kinase-interacting kinases--emerging targets against cancer.
@en
P2093
Malika Kumarasiri
Sarah Diab
Shudong Wang
Theodosia Teo
P304
P356
10.1016/J.CHEMBIOL.2014.01.011
P577
2014-03-06T00:00:00Z