Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia. - Wikidata - wikimedia - TriplyDB

Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.

Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.

http://www.wikidata.org/entity/Q35116967

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The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis The Genetic Architecture of Murine Glutathione Transferases Role of casein kinase 1A1 in the biology and targeted therapy of del(5q) MDS.Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.Targeting Csnk1a1 in leukemia.Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers.Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML The interplay between HPIP and casein kinase 1α promotes renal cell carcinoma growth and metastasis via activation of mTOR pathway.Inactivation of CK1α in multiple myeloma empowers drug cytotoxicity by affecting AKT and β-catenin survival signaling pathways.Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis.Therapy-related myeloid neoplasms: when genetics and environment collide.Casein kinases as potential therapeutic targets.A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes Cereblon and its downstream substrates as molecular targets of immunomodulatory drugs.CK1δ in lymphoma: gene expression and mutation analyses and validation of CK1δ kinase activity for therapeutic application.Role of protein kinases CK1α and CK2 in multiple myeloma: regulation of pivotal survival and stress-managing pathways.Frequency and prognostic impact of casein kinase 1A1 mutations in MDS patients with deletion of chromosome 5q.Interleukin 4 induces apoptosis of acute myeloid leukemia cells in a Stat6-dependent manner.Cereblon: A Protein Crucial to the Multiple Functions of Immunomodulatory Drugs as well as Cell Metabolism and Disease Generation.Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis.CSNK1a1 Regulates PRMT1 to Maintain the Progenitor State in Self-Renewing Somatic Tissue.CK1α overexpression correlates with poor survival in colorectal cancer.A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.The role of p53 in myelodysplastic syndromes and acute myeloid leukemia: molecular aspects and clinical implications.Myeloid disease: Another action of a thalidomide derivative.Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism.

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Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.

http://www.wikidata.org/entity/Q35116967

description

2014 nî lūn-bûn

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2014 թուականի Մարտին հրատարակուած գիտական յօդուած

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2014 թվականի մարտին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.

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Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.

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type

label

Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.

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Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.

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prefLabel

Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.

@ast

Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.

@en

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Journal of Experimental Medicine

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Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia

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Ann Mullally

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Benjamin L Ebert

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David E Root

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Emma C Fink

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Fatima Al-Shahrour

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Glenn S Cowley

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Kimberly A Hartwell

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L Jordan Breyfogle

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Lisa P Chu

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Marie E McConkey

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P2860

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction

Modeling the initiation and progression of human acute leukemia in mice

KEGG for integration and interpretation of large-scale molecular data sets

The origin and evolution of mutations in acute myeloid leukemia

A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen

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605-612

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10.1084/JEM.20131033

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Michael G Kharas

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260684557

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