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A common pharmacophore for cytotoxic natural products that stabilize microtubules

A common pharmacophore for cytotoxic natural products that stabilize microtubules

http://www.wikidata.org/entity/Q35123238

about

The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density Stabilizing versus destabilizing the microtubules: a double-edge sword for an effective cancer treatment option?Cancer wars: natural products strike back Epothilones: From discovery to clinical trials Understanding the basis of drug resistance of the mutants of αβ-tubulin dimer via molecular dynamics simulations Pharmacophore modeling and in silico toxicity assessment of potential anticancer agents from African medicinal plants A natural love of natural products.A structure-based design of new C2- and C13-substituted taxanes: tubulin binding affinities and extended quantitative structure-activity relationships using comparative binding energy (COMBINE) analysis.Nordihydroguaiaretic acid, of a new family of microtubule-stabilizing agents, shows effects differentiated from paclitaxel.Total synthesis and evaluation of 22-(3-azidobenzoyloxy)methyl epothilone C for photoaffinity labeling of beta-tubulin.Iron complexation to oxygen rich marine natural products: a computational study.Rotational-echo double-resonance NMR distance measurements for the tubulin-bound Paclitaxel conformation The quest for a simple bioactive analog of paclitaxel as a potential anticancer agent.Drug discovery targeting cell division proteins, microtubules and FtsZ.Chemistry and chemical biology of taxane anticancer agents.Recent advances in the study of the bioactive conformation of taxol A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells.Understanding tubulin-Taxol interactions: mutations that impart Taxol binding to yeast tubulin.Cellular studies reveal mechanistic differences between taccalonolide A and paclitaxel.C6-C8 bridged epothilones: consequences of installing a conformational lock at the edge of the macrocycle.The bioactive Taxol conformation on beta-tubulin: experimental evidence from highly active constrained analogs.The shape of things to come: structural and synthetic studies of taxol and related compounds Anticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents.Bridging converts a noncytotoxic nor-paclitaxel derivative to a cytotoxic analogue by constraining it to the T-Taxol conformation.Evaluation of the tubulin-bound paclitaxel conformation: synthesis, biology, and SAR studies of C-4 to C-3' bridged paclitaxel analogues Epothilones: a novel class of microtubule-stabilizing drugs for the treatment of cancer.Ixabepilone: a new chemotherapeutic option for refractory metastatic breast cancer Design, synthesis, and biological evaluation of novel C14-C3'BzN-linked macrocyclic taxoids.Design, synthesis and biological evaluation of bridged epothilone D analogues.Microtubule stabilising agents for cancer chemotherapy.Targeting microtubules by natural agents for cancer therapy.Modulation of protein-protein interactions as a therapeutic strategy for the treatment of neurodegenerative tauopathies.Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.Tubulin: an example of targeted chemotherapy.Structural studies of taxol analogues for drug discovery.Role of tumor necrosis factor alpha-induced protein 1 in paclitaxel resistance.Molecular dynamics and tubulin polymerization kinetics study on 1,14-heterofused taxanes: evidence of stabilization of the tubulin head-to-tail dimer-dimer interaction.A novel C,D-spirolactone analogue of paclitaxel: autophagy instead of apoptosis as a previously unknown mechanism of cytotoxic action for taxoids.The binding mode of side chain- and C3-modified epothilones to tubulin.Synthesis and bioactivity of a side chain bridged paclitaxel: A test of the T-Taxol conformation.

P2860

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P2860

A common pharmacophore for cytotoxic natural products that stabilize microtubules

http://www.wikidata.org/entity/Q35123238

description

1999 nî lūn-bûn

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1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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1999 թվականի ապրիլին հրատարակված գիտական հոդված

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1999年の論文

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1999年学术文章

@wuu

1999年学术文章

@zh-cn

1999年学术文章

@zh-hans

1999年学术文章

@zh-my

1999年学术文章

@zh-sg

1999年學術文章

@yue

name

A common pharmacophore for cytotoxic natural products that stabilize microtubules

@ast

A common pharmacophore for cytotoxic natural products that stabilize microtubules

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type

label

A common pharmacophore for cytotoxic natural products that stabilize microtubules

@ast

A common pharmacophore for cytotoxic natural products that stabilize microtubules

@en

prefLabel

A common pharmacophore for cytotoxic natural products that stabilize microtubules

@ast

A common pharmacophore for cytotoxic natural products that stabilize microtubules

@en

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Proceedings of the National Academy of Sciences of the United States of America

P1476

A common pharmacophore for cytotoxic natural products that stabilize microtubules

@en

P2093

Chakravarty S

http://www.w3.org/2001/XMLSchema#string

Danishefsky SJ

http://www.w3.org/2001/XMLSchema#string

He L

http://www.w3.org/2001/XMLSchema#string

Horwitz SB

http://www.w3.org/2001/XMLSchema#string

Inoue T

http://www.w3.org/2001/XMLSchema#string

Kuduk SD

http://www.w3.org/2001/XMLSchema#string

Lin S

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Ojima I

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P2860

Structure of the alpha beta tubulin dimer by electron crystallography

Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel.

Crystal and molecular structure of paclitaxel (taxol).

Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action.

Desoxyepothilone B: an efficacious microtubule-targeted antitumor agent with a promising in vivo profile relative to epothilone B.

Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations

Taxol: a novel investigational antimicrotubule agent.

Syntheses and structure-activity relationships of taxoids derived from 14 beta-hydroxy-10-deacetylbaccatin III.

Syntheses and structure-activity relationships of the second-generation antitumor taxoids: exceptional activity against drug-resistant cancer cells.

(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest.

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4256-4261

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scholarly article

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10.1073/PNAS.96.8.4256

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P433

8

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96

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1999-04-01T00:00:00Z

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24448050

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10200249

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P932

16319

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