SUMOylation of the human cytomegalovirus 72-kilodalton IE1 protein facilitates expression of the 86-kilodalton IE2 protein and promotes viral replication
about
Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo.Analysis of human cytomegalovirus-encoded SUMO targets and temporal regulation of SUMOylation of the immediate-early proteins IE1 and IE2 during infectionFlaviviral NS4b, chameleon and jack-in-the-box roles in viral replication and pathogenesis, and a molecular target for antiviral interventionAn HIV feedback resistor: auto-regulatory circuit deactivator and noise bufferHuman cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNAInhibition of human cytomegalovirus immediate-early gene expression by cyclin A2-dependent kinase activityHuman cytomegalovirus major immediate early 1 protein targets host chromosomes by docking to the acidic pocket on the nucleosome surface.Functional interaction between human herpesvirus 6 immediate-early 2 protein and ubiquitin-conjugating enzyme 9 in the absence of sumoylation.Sumoylation of the Epstein-Barr virus BZLF1 protein inhibits its transcriptional activity and is regulated by the virus-encoded protein kinase.Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-γRole of noncovalent SUMO binding by the human cytomegalovirus IE2 transactivator in lytic growth.Innate antiviral response targets HIV-1 release by the induction of ubiquitin-like protein ISG15.A human cytomegalovirus antagonist of type I IFN-dependent signal transducer and activator of transcription signalingTranscriptional activation of endoplasmic reticulum chaperone GRP78 by HCMV IE1-72 proteinThe late promoter of the human cytomegalovirus viral DNA polymerase processivity factor has an impact on delayed early and late viral gene products but not on viral DNA synthesisHuman Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFNγ-Like ResponseAn endogenous accelerator for viral gene expression confers a fitness advantage.The replication defect of ICP0-null mutant herpes simplex virus 1 can be largely complemented by the combined activities of human cytomegalovirus proteins IE1 and pp71Development of a high-throughput assay to measure the neutralization capability of anti-cytomegalovirus antibodies.Regulation of the nucleocytoplasmic trafficking of viral and cellular proteins by ubiquitin and small ubiquitin-related modifiers.Binding STAT2 by the acidic domain of human cytomegalovirus IE1 promotes viral growth and is negatively regulated by SUMO.Human cytomegalovirus IE1 protein disrupts interleukin-6 signaling by sequestering STAT3 in the nucleus.SUMO Modification Stabilizes Enterovirus 71 Polymerase 3D To Facilitate Viral Replication.Physical requirements and functional consequences of complex formation between the cytomegalovirus IE1 protein and human STAT2.Analysis of essential viral gene functions after highly efficient adenofection of cells with cloned human cytomegalovirus genomes.Human cytomegalovirus immediate-early 1 protein facilitates viral replication by antagonizing histone deacetylation.Human pathogens and the host cell SUMOylation system.Viral manipulation of cellular protein conjugation pathways: The SUMO lesson.Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome.Deletion of the rat cytomegalovirus immediate-early 1 gene results in a virus capable of establishing latency, but with lower levels of acute virus replication and latency that compromise reactivation efficiency.Analysis of the functional interchange between the IE1 and pp71 proteins of human cytomegalovirus and ICP0 of herpes simplex virus 1.Manipulation of ubiquitin/SUMO pathways in human herpesviruses infection.Human cytomegalovirus IE72 protein interacts with the transcriptional repressor hDaxx to regulate LUNA gene expression during lytic infection.Internal deletions of IE2 86 and loss of the late IE2 60 and IE2 40 proteins encoded by human cytomegalovirus affect the levels of UL84 protein but not the amount of UL84 mRNA or the loading and distribution of the mRNA on polysomesHuman cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligase.Viral Interplay with the Host Sumoylation System.Analysis of human cytomegalovirus replication in primary cultured human corneal endothelial cells.Human cytomegalovirus early protein pUL21a promotes efficient viral DNA synthesis and the late accumulation of immediate-early transcripts.
P2860
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P2860
SUMOylation of the human cytomegalovirus 72-kilodalton IE1 protein facilitates expression of the 86-kilodalton IE2 protein and promotes viral replication
description
2004 nî lūn-bûn
@nan
2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2004年の論文
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2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
name
SUMOylation of the human cytom ...... and promotes viral replication
@ast
SUMOylation of the human cytom ...... and promotes viral replication
@en
type
label
SUMOylation of the human cytom ...... and promotes viral replication
@ast
SUMOylation of the human cytom ...... and promotes viral replication
@en
prefLabel
SUMOylation of the human cytom ...... and promotes viral replication
@ast
SUMOylation of the human cytom ...... and promotes viral replication
@en
P2860
P1433
P1476
SUMOylation of the human cytom ...... and promotes viral replication
@en
P2093
Thomas Shenk
P2860
P304
P356
10.1128/JVI.78.14.7803-7812.2004
P407
P577
2004-07-01T00:00:00Z