Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.
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Tumor-intrinsic oncogene pathways mediating immune avoidanceObesity-Driven Gut Microbiota Inflammatory Pathways to Metabolic SyndromeFunctional significance of macrophages in pancreatic cancer biologyPhosphoinositide 3-kinase: friend and foe in cardiovascular diseaseMyeloid Cells as Targets for Therapy in Solid TumorsLeukocyte integrins: role in leukocyte recruitment and as therapeutic targets in inflammatory diseaseTargeting p110gamma in gastrointestinal cancers: attack on multiple frontsIntertwined regulation of angiogenesis and immunity by myeloid cellsTargeting interleukin-1 in heart diseasePI3Kγ Is Critical for Dendritic Cell-Mediated CD8+ T Cell Priming and Viral Clearance during Influenza Virus InfectionA selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiationInactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancerInflammation and skeletal metastasisPI3K at the crossroads of tumor angiogenesis signaling pathwaysTargeting PI3K in cancer: impact on tumor cells, their protective stroma, angiogenesis and immunotherapyPI3K and cancer: lessons, challenges and opportunitiesVEGF-A recruits a proangiogenic MMP-9-delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissueMolecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs)Effects of novel isoform-selective phosphoinositide 3-kinase inhibitors on natural killer cell function.PI3Kγ is a molecular switch that controls immune suppressionImpact of tumour associated macrophages in pancreatic cancer.Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells.Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling.Big opportunities for small molecules in immuno-oncology.PI3-kinase γ promotes Rap1a-mediated activation of myeloid cell integrin α4β1, leading to tumor inflammation and growthRac2 controls tumor growth, metastasis and M1-M2 macrophage differentiation in vivo.PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.Stat1 stimulates cap-independent mRNA translation to inhibit cell proliferation and promote survival in response to antitumor drugsIntratumoral myeloid cells regulate responsiveness and resistance to antiangiogenic therapy.Combined blockade of integrin-α4β1 plus cytokines SDF-1α or IL-1β potently inhibits tumor inflammation and growthThe role of phosphoinositide 3-kinase signaling in intestinal inflammationTumor and Host Factors Controlling Antitumor Immunity and Efficacy of Cancer Immunotherapy.The phosphoinositide-3-kinase (PI3K)-delta and gamma inhibitor, IPI-145 (Duvelisib), overcomes signals from the PI3K/AKT/S6 pathway and promotes apoptosis in CLL.Identification and characterization of VEGF-A-responsive neutrophils expressing CD49d, VEGFR1, and CXCR4 in mice and humans.The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic DiseasesDifferent inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapyPI3K signalling in B- and T-lymphocytes: new developments and therapeutic advancesp110δ PI3 kinase pathway: emerging roles in cancer.Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway
P2860
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P2860
Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
name
Receptor tyrosine kinases and ...... inflammation and progression.
@ast
Receptor tyrosine kinases and ...... inflammation and progression.
@en
type
label
Receptor tyrosine kinases and ...... inflammation and progression.
@ast
Receptor tyrosine kinases and ...... inflammation and progression.
@en
prefLabel
Receptor tyrosine kinases and ...... inflammation and progression.
@ast
Receptor tyrosine kinases and ...... inflammation and progression.
@en
P2093
P2860
P50
P921
P1433
P1476
Receptor tyrosine kinases and ...... r inflammation and progression
@en
P2093
Christie J Avraamides
David A Cheresh
Holly C Dippold
Joan R E Manglicmot
Lesley G Ellies
Lissette M Acevedo
Mark H Ginsberg
Philippe Foubert
Sara L Blair
Wolfgang Wrasidlo
P2860
P304
P356
10.1016/J.CCR.2011.04.016
P577
2011-06-01T00:00:00Z