Role of TRIM5α RING domain E3 ubiquitin ligase activity in capsid disassembly, reverse transcription blockade, and restriction of simian immunodeficiency virus.
about
TRIM5α and Species Tropism of HIV/SIVRecruitment and dynamics of proteasome association with rhTRIM5α cytoplasmic complexes during HIV-1 infection.Stabilized human TRIM5α protects human T cells from HIV-1 infection.Contribution of glutamine residues in the helix 4-5 loop to capsid-capsid interactions in simian immunodeficiency virus of macaques.TRIM38 negatively regulates TLR3-mediated IFN-β signaling by targeting TRIF for degradation.Delaying reverse transcription does not increase sensitivity of HIV-1 to human TRIM5α.Potent restriction of HIV-1 and SIVmac239 replication by African green monkey TRIM5α.African green monkey TRIM5α restriction in simian immunodeficiency virus-specific rhesus macaque effector CD4 T cells enhances their survival and antiviral function.RING domain mutations uncouple TRIM5α restriction of HIV-1 from inhibition of reverse transcription and acceleration of uncoatingRole of Human TRIM5α in Intrinsic Immunity.SJP-L-5, a novel small-molecule compound, inhibits HIV-1 infection by blocking viral DNA nuclear entry.RING Dimerization Links Higher-Order Assembly of TRIM5α to Synthesis of K63-Linked Polyubiquitin.TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription.Contribution of SUMO-interacting motifs and SUMOylation to the antiretroviral properties of TRIM5α.Virus-specific effects of TRIM5α(rh) RING domain functions on restriction of retroviruses.Pressure from TRIM5α contributes to control of HIV-1 replication by individuals expressing protective HLA-B alleles.Gag cytotoxic T lymphocyte escape mutations can increase sensitivity of HIV-1 to human TRIM5alpha, linking intrinsic and acquired immunity.Retrovirus restriction by TRIM5 proteins requires recognition of only a small fraction of viral capsid subunits.Binding of the rhesus TRIM5α PRYSPRY domain to capsid is necessary but not sufficient for HIV-1 restriction.A general model for retroviral capsid pattern recognition by TRIM5 proteins.Rhesus monkey TRIM5alpha SPRY domain contributes to AP-1 activation.
P2860
Q24304062-615DB95F-B364-43C3-AF29-9D69A29747E8Q30543944-696D1B29-42C8-42F5-B645-296F19EBF8FBQ33724266-94A83F91-5B3E-4C6C-A115-261AA87E8391Q34262274-8EBBFA99-A09F-42DA-A543-4CCD05A7E1C7Q34442208-B4F24138-CBC5-42F8-BB66-F6626FB77AC5Q34548171-5060A068-DDEA-4F39-9019-AA56ABCAC599Q35142600-4A5C583C-1DB5-4D56-AD72-DC8424093341Q35641022-8FD3D166-5435-468F-8768-EABDEB24241DQ35689590-A7438526-D534-4DE3-A14B-0D97FC812994Q35831267-EEBD185E-52F1-435B-8D1D-62CA795C0FD5Q35859394-2E4A03A2-435B-413F-A8C5-8AFC0DF82CD0Q35921992-7D79C468-53DF-4D27-A5C1-00C46E3754F7Q36000845-06A73C06-19E8-4D66-9D84-465DF6D0B971Q36501796-F353714C-0DEF-4007-BC01-2C71DACFFF6FQ36978951-8454EE14-4085-4A24-B990-5E1B304E9B43Q37123118-B366C2D6-E669-41CA-87C8-D332B9F8190AQ38959897-D5F99C9A-0294-447A-9BF7-66DFBEEA49C3Q39137377-0ACD1005-2B3E-4E6F-8348-185B0EC8F422Q41889046-989289CD-4EA9-41AF-A9FE-2EE0DF50F44CQ45074273-38C16787-2FC7-41B3-98DD-536232AAA3D9Q47570473-BCFEA5A9-7EB6-425A-A424-DBFE96EA3830
P2860
Role of TRIM5α RING domain E3 ubiquitin ligase activity in capsid disassembly, reverse transcription blockade, and restriction of simian immunodeficiency virus.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Role of TRIM5α RING domain E3 ...... simian immunodeficiency virus.
@ast
Role of TRIM5α RING domain E3 ...... simian immunodeficiency virus.
@en
type
label
Role of TRIM5α RING domain E3 ...... simian immunodeficiency virus.
@ast
Role of TRIM5α RING domain E3 ...... simian immunodeficiency virus.
@en
prefLabel
Role of TRIM5α RING domain E3 ...... simian immunodeficiency virus.
@ast
Role of TRIM5α RING domain E3 ...... simian immunodeficiency virus.
@en
P2860
P356
P1433
P1476
Role of TRIM5α RING domain E3 ...... simian immunodeficiency virus.
@en
P2093
Christopher Tipper
Jonghwa Kim
P2860
P304
P356
10.1128/JVI.00341-11
P407
P577
2011-06-15T00:00:00Z