Altered trafficking and stability of polycystins underlie polycystic kidney disease. - Wikidata - wikimedia - TriplyDB

Altered trafficking and stability of polycystins underlie polycystic kidney disease.

Altered trafficking and stability of polycystins underlie polycystic kidney disease.

http://www.wikidata.org/entity/Q35145360

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Ciliary Extracellular Vesicles: Txt Msg Organelles The Role of G-Protein-Coupled Receptor Proteolysis Site Cleavage of Polycystin-1 in Renal Physiology and Polycystic Kidney Disease Role of the Polycystins in Cell Migration, Polarity, and Tissue Morphogenesis A polycystin-centric view of cyst formation and disease: the polycystins revisited Model Organisms in G Protein-Coupled Receptor Research Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutant Trafficking to the primary cilium membrane.Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity.Myristoylated CIL-7 regulates ciliary extracellular vesicle biogenesis Human polycystin-2 transgene dose-dependently rescues ADPKD phenotypes in Pkd2 mutant mice.Cell-Specific Transcriptional Profiling of Ciliated Sensory Neurons Reveals Regulators of Behavior and Extracellular Vesicle Biogenesis An age of enlightenment for cilia: The FASEB summer research conference on the "Biology of Cilia and Flagella"mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex.The Polycystin-1, Lipoxygenase, and α-Toxin Domain Regulates Polycystin-1 Trafficking.Fatty Acid Oxidation is Impaired in An Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney Disease.Heterotrimeric G protein signaling in polycystic kidney disease Progress in ciliary ion channel physiology.MAPK-15 is a ciliary protein required for PKD-2 localization and male mating behavior in Caenorhabditis elegans.Isolated polycystic liver disease genes define effectors of polycystin-1 function.Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins Role of apoptosis in the development of autosomal dominant polycystic kidney disease (ADPKD).PKD2-Related Autosomal Dominant Polycystic Kidney Disease: Prevalence, Clinical Presentation, Mutation Spectrum, and Prognosis.Predicted Mutation Strength of Nontruncating PKD1 Mutations Aids Genotype-Phenotype Correlations in Autosomal Dominant Polycystic Kidney Disease Extracellular Loops Are Essential for the Assembly and Function of Polycystin Receptor-Ion Channel Complexes.Primary Cilia in Cystic Kidney Disease.The serologically defined colon cancer antigen-3 (SDCCAG3) is involved in the regulation of ciliogenesis.Molecular diagnosis of autosomal dominant polycystic kidney disease.Phosphoinositide 3-Kinase-C2α Regulates Polycystin-2 Ciliary Entry and Protects against Kidney Cyst Formation.Rapamycin treatment dose-dependently improves the cystic kidney in a new ADPKD mouse model via the mTORC1 and cell-cycle-associated CDK1/cyclin axis.Genetic Complexity of Autosomal Dominant Polycystic Kidney and Liver Diseases.Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease.A cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed.Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium.The Genetic and Cellular Basis of Autosomal Dominant Polycystic Kidney Disease-A Primer for Clinicians.Ciliary Mechanisms of Cyst Formation in Polycystic Kidney Disease.Polycystin 1 loss of function is directly linked to an imbalance in G-protein signaling in the kidney.Adhesion GPCRs in Kidney Development and Disease.

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P2860

Altered trafficking and stability of polycystins underlie polycystic kidney disease.

http://www.wikidata.org/entity/Q35145360

description

2014 nî lūn-bûn

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2014 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Altered trafficking and stability of polycystins underlie polycystic kidney disease.

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Altered trafficking and stability of polycystins underlie polycystic kidney disease.

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type

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Altered trafficking and stability of polycystins underlie polycystic kidney disease.

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Altered trafficking and stability of polycystins underlie polycystic kidney disease.

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prefLabel

Altered trafficking and stability of polycystins underlie polycystic kidney disease.

@ast

Altered trafficking and stability of polycystins underlie polycystic kidney disease.

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P1433

Journal of Clinical Investigation

P1476

Altered trafficking and stability of polycystins underlie polycystic kidney disease.

@en

P2093

Ann-Hwee Lee

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Anna-Rachel Gallagher

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Dayne Okuhara

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Georgia Anyatonwu

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Jian-Dong Gao

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Ke Dong

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Maria D Lalioti

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Michihiro Mitobe

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Sorin V Fedeles

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Stefan Somlo

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P2860

Polycystin-2 is an intracellular calcium release channel

A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes

Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2

Direct recording and molecular identification of the calcium channel of primary cilia.

Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation

PKD1 interacts with PKD2 through a probable coiled-coil domain

Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations.

The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains

The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease.

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

P304

5129-5144

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scholarly article

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10.1172/JCI67273

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P433

12

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124

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Barbara E Ehrlich

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2014-11-03T00:00:00Z

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25365220

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4348948

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