A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses. - Wikidata - wikimedia - TriplyDB

A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses.

A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses.

http://www.wikidata.org/entity/Q35147460

about

MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mimetics.Fever Binding specificity of Toll-like receptor cytoplasmic domains Toll-Like Receptors in the Pathogenesis of Autoimmune Diseases Toll-like receptors in systemic lupus erythematosus: potential targets for therapeutic intervention Role of innate immunity in the development of hepatocellular carcinoma The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer Inflammasome-associated nucleotide-binding domain, leucine-rich repeat proteins and inflammatory diseases Structural and functional evidence for the role of the TLR2 DD loop in TLR1/TLR2 heterodimerization and signaling Toll-Like Receptors and Cancer: MYD88 Mutation and Inflammation.MyD88 signaling regulates both host defense and immunopathogenesis during pneumocystis infection Glaucomatous tissue stress and the regulation of immune response through glial Toll-like receptor signaling A small molecule that mimics the BB-loop in the Toll interleukin-1 (IL-1) receptor domain of MyD88 attenuates staphylococcal enterotoxin B-induced pro-inflammatory cytokine production and toxicity in mice Innate immune recognition of nucleic acids.Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus.Mammalian Toll-like receptors: to immunity and beyond.From cellular receptors to transduction-transcription pathways for cytokines: at which level should the inhibition be targeted in inflammation?The critical role of toll-like receptors--From microbial recognition to autoimmunity: A comprehensive review.Sepsis-induced organ failure is mediated by different pathways in the kidney and liver: acute renal failure is dependent on MyD88 but not renal cell apoptosis.Targeting protein-protein interactions by rational design: mimicry of protein surfaces Suppression of TLR signaling by targeting TIR domain-containing proteins Cell-penetrating TIR BB loop decoy peptides a novel class of TLR signaling inhibitors and a tool to study topology of TIR-TIR interactions.Toll-like receptors, RIG-I-like RNA helicases and the antiviral innate immune response.Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins.Accelerated prion disease pathogenesis in Toll-like receptor 4 signaling-mutant mice.Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL-1β/IL-1R1/MyD88/NF-κB pathway.Targeting TLR/IL-1R signalling in human diseases.Targeting Toll-like receptors for treatment of SLE Toll-like receptor signaling pathways--therapeutic opportunities.Treating atherosclerosis: the potential of Toll-like receptors as therapeutic targets.Role of Toll-like receptors in liver health and disease.Taming inflammation by targeting cytokine signaling: new perspectives in the induction of transplantation tolerance.Toll/interleukin-1 receptor (TIR) domain-mediated cellular signaling pathways.Rational design of peptide derivatives for inhibition of MyD88-mediated toll-like receptor signaling in human peripheral blood mononuclear cells and epithelial cells exposed to Francisella tularensis.The Role of Toll-Like Receptors in Autoimmune Diseases through Failure of the Self-Recognition Mechanism.Mutational analysis identifies residues crucial for homodimerization of myeloid differentiation factor 88 (MyD88) and for its function in immune cells.Cytokines and cytokine networks target neurons to modulate long-term potentiation.Targeting of MyD88 Homodimerization by Novel Synthetic Inhibitor TJ-M2010-5 in Preventing Colitis-Associated Colorectal Cancer.Identification of interaction sites for dimerization and adapter recruitment in Toll/interleukin-1 receptor (TIR) domain of Toll-like receptor 4.

P2860

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P2860

A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses.

http://www.wikidata.org/entity/Q35147460

description

2003 nî lūn-bûn

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2003年の論文

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A low molecular weight mimic o ...... 1 receptor-mediated responses.

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A low molecular weight mimic o ...... 1 receptor-mediated responses.

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A low molecular weight mimic o ...... 1 receptor-mediated responses.

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A low molecular weight mimic o ...... 1 receptor-mediated responses.

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A low molecular weight mimic o ...... 1 receptor-mediated responses.

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Alexander Shivanyuk

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Janell Pemberton

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M Margarita Behrens

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Svetlana Gaidarova

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P2860

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts

Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells

Regulation of interleukin-1- and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88

Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6

MyD88, an adapter protein involved in interleukin-1 signaling

Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

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