The angular structure of ONC201, a TRAIL pathway-inducing compound, determines its potent anti-cancer activity.

The angular structure of ONC201, a TRAIL pathway-inducing compound, determines its potent anti-cancer activity.

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http://www.wikidata.org/entity/Q35149642
Identification of DNA-PKcs as a primary resistance factor of TIC10 in hepatocellular carcinoma cells.TIC10/ONC201: a bend in the road to clinical developmentIdentification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathwayFirst-In-Class Small Molecule ONC201 Induces DR5 and Cell Death in Tumor but Not Normal Cells to Provide a Wide Therapeutic Index as an Anti-Cancer AgentSmall Molecular TRAIL Inducer ONC201 Induces Death in Lung Cancer Cells: A Preclinical Study.Discovery and clinical introduction of first-in-class imipridone ONC201.Neuro-oncology biotech industry progress report.ONC201 induces cell death in pediatric non-Hodgkin's lymphoma cells.ONC201 selectively induces apoptosis in cutaneous T-cell lymphoma cells via activating pro-apoptotic integrated stress response and inactivating JAK/STAT and NF-κB pathways.Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212.Anti-tumor effects of ONC201 in combination with VEGF-inhibitors significantly impacts colorectal cancer growth and survival in vivo through complementary non-overlapping mechanisms.Dose intensification of TRAIL-inducing ONC201 inhibits metastasis and promotes intratumoral NK cell recruitment.ONC201: a new treatment option being tested clinically for recurrent glioblastomaFerrocene-Containing Impiridone (ONC201) Hybrids: Synthesis, DFT Modelling, In Vitro Evaluation, and Structure⁻Activity Relationships
P2860

The angular structure of ONC201, a TRAIL pathway-inducing compound, determines its potent anti-cancer activity.

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http://www.wikidata.org/entity/Q35149642
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2014 nî lūn-bûn
@nan
2014 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
The angular structure of ONC20 ...... s potent anti-cancer activity.
@ast
The angular structure of ONC20 ...... s potent anti-cancer activity.
@en
type
label
The angular structure of ONC20 ...... s potent anti-cancer activity.
@ast
The angular structure of ONC20 ...... s potent anti-cancer activity.
@en
prefLabel
The angular structure of ONC20 ...... s potent anti-cancer activity.
@ast
The angular structure of ONC20 ...... s potent anti-cancer activity.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P932
P356
P1433
P1476
The angular structure of ONC20 ...... s potent anti-cancer activity.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P932