Loss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones.
about
Defective control of pre-messenger RNA splicing in human diseaseOxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutationsMolecular network analysis suggests a logical hypothesis for the pathological role of c9orf72 in amyotrophic lateral sclerosis/frontotemporal dementia.Invited review: decoding the pathophysiological mechanisms that underlie RNA dysregulation in neurodegenerative disorders: a review of the current state of the art.Old versus New Mechanisms in the Pathogenesis of ALS.Tau mis-splicing in the pathogenesis of neurodegenerative disorders.TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathwaysFailure to Deliver and Translate-New Insights into RNA Dysregulation in ALS.Genetic mutations in RNA-binding proteins and their roles in ALS.Split GFP technologies to structurally characterize and quantify functional biomolecular interactions of FTD-related proteinsAdvances, challenges and future directions for stem cell therapy in amyotrophic lateral sclerosis.Genomic and Proteomic Resolution of Heterochromatin and Its Restriction of Alternate Fate Genes.Cell Type-Specific Laser Capture Microdissection for Gene Expression Profiling in the Human Brain.Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons.Motor neurone disease/amyotrophic lateral sclerosis associated with intermediate-length CAG repeat expansions in Ataxin-2 does not have 1C2-positive polyglutamine inclusions.Axonal TDP-43 aggregates in sporadic amyotrophic lateral sclerosis.Unraveling the Role of RNA Mediated Toxicity of C9orf72 Repeats in C9-FTD/ALS.A Metadata Analysis of Oxidative Stress Etiology in Preclinical Amyotrophic Lateral Sclerosis: Benefits of Antioxidant Therapy.TDP43 and RNA instability in amyotrophic lateral sclerosis.
P2860
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P2860
Loss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones.
description
2014 nî lūn-bûn
@nan
2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Loss of nuclear TDP-43 in amyo ...... NA splicing in motor neurones.
@ast
Loss of nuclear TDP-43 in amyo ...... NA splicing in motor neurones.
@en
type
label
Loss of nuclear TDP-43 in amyo ...... NA splicing in motor neurones.
@ast
Loss of nuclear TDP-43 in amyo ...... NA splicing in motor neurones.
@en
prefLabel
Loss of nuclear TDP-43 in amyo ...... NA splicing in motor neurones.
@ast
Loss of nuclear TDP-43 in amyo ...... NA splicing in motor neurones.
@en
P2093
P2860
P50
P356
P1476
Loss of nuclear TDP-43 in amyo ...... RNA splicing in motor neurones
@en
P2093
Adrian Higginbottom
Channa A Hewamadduma
Christopher J McDermott
Joeri A Jansweijer
Paul G Ince
Paul R Heath
Philip S Webb
Rohini Raman
Stephen B Wharton
P2860
P304
P356
10.1111/NAN.12148
P577
2014-10-01T00:00:00Z