RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis. - Wikidata - wikimedia - TriplyDB

RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis.

RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis.

http://www.wikidata.org/entity/Q35159034

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MicroRNAs in multiple myeloma and related bone disease Role of microRNAs in chemoresistance Metabolic reprogramming in cancer cells: glycolysis, glutaminolysis, and Bcl-2 proteins as novel therapeutic targets for cancer Narrowing the focus: a toolkit to systematically connect oncogenic signaling pathways with cancer phenotypes Cancer stem cell metabolism: a potential target for cancer therapy Mapping the Pathways of Resistance to Targeted Therapies Lentiginoses in polycythemia vera patient: Is there a role for JAK2 (V617F) mutation?Developmental transcriptome analysis and identification of genes involved in formation of intestinal air-breathing function of Dojo loach, Misgurnus anguillicaudatus The PIM inhibitor AZD1208 synergizes with ruxolitinib to induce apoptosis of ruxolitinib sensitive and resistant JAK2-V617F-driven cells and inhibit colony formation of primary MPN cells.Targeting MCL-1/BCL-XL Forestalls the Acquisition of Resistance to ABT-199 in Acute Myeloid Leukemia.Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics - recent successes, current challenges and future promise.MicroRNAs, signaling pathways and diseases.Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance.JAK2 aberrations in childhood B-cell precursor acute lymphoblastic leukemia.Why do BCL-2 inhibitors work and where should we use them in the clinic?Targeting Rho GTPase effector p21 activated kinase 4 (PAK4) suppresses p-Bad-microRNA drug resistance axis leading to inhibition of pancreatic ductal adenocarcinoma proliferation.A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution.BAK is a predictive and prognostic biomarker for the therapeutic effect of docetaxel treatment in patients with advanced gastric cancer.IL-5 blocks apoptosis and tau hyperphosphorylation induced by Aβ25-35 peptide in PC12 cells.p53 pathway dysfunction is highly prevalent in acute myeloid leukemia independent of TP53 mutational status.Novel Therapies for Myelofibrosis.

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P2860

RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis.

http://www.wikidata.org/entity/Q35159034

description

2014 nî lūn-bûn

@nan

2014 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2014年の論文

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2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

RAS signaling promotes resista ...... essing BAD-mediated apoptosis.

@ast

RAS signaling promotes resista ...... essing BAD-mediated apoptosis.

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type

label

RAS signaling promotes resista ...... essing BAD-mediated apoptosis.

@ast

RAS signaling promotes resista ...... essing BAD-mediated apoptosis.

@en

prefLabel

RAS signaling promotes resista ...... essing BAD-mediated apoptosis.

@ast

RAS signaling promotes resista ...... essing BAD-mediated apoptosis.

@en

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SCISIGNAL.2005301

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Science Signaling

P1476

RAS signaling promotes resista ...... essing BAD-mediated apoptosis.

@en

P2093

Anthony Letai

http://www.w3.org/2001/XMLSchema#string

Kevin H Lin

http://www.w3.org/2001/XMLSchema#string

Kris C Wood

http://www.w3.org/2001/XMLSchema#string

Kristopher A Sarosiek

http://www.w3.org/2001/XMLSchema#string

Peter S Winter

http://www.w3.org/2001/XMLSchema#string

P2860

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents

Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera.

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase

Targeting RAS signalling pathways in cancer therapy

CYT387, a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

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ra122

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scholarly article

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10.1126/SCISIGNAL.2005301

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357

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7

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Manja Meggendorfer

Susanne Schnittger

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2014-12-23T00:00:00Z

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25538080

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4353591

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