about
Neuronal preconditioning by inhalational anesthetics: evidence for the role of plasmalemmal adenosine triphosphate-sensitive potassium channelsDrugs acting on SUR1 to treat CNS ischemia and traumaNewly expressed SUR1-regulated NC(Ca-ATP) channel mediates cerebral edema after ischemic strokeMechanisms of action of glucagon-like peptide 1 in the pancreasHyperinsulinemic Hypoglycemia - The Molecular MechanismsMolecular pathophysiology of cerebral edemaMolecular action of sulphonylureas on KATP channels: a real partnership between drugs and nucleotidesNeuronal and Cardiovascular Potassium Channels as Therapeutic Drug Targets: Promise and PitfallsImpact of hypoglycemic agents on myocardial ischemic preconditioningSystemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of RodentsA heterozygous activating mutation in the sulphonylurea receptor SUR1 (ABCC8) causes neonatal diabetes.Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactionsTetrameric structure of SUR2B revealed by electron microscopy of oriented single particlesD-chiro-inositol glycan stimulates insulin secretion in pancreatic β cells.Glibenclamide is superior to decompressive craniectomy in a rat model of malignant stroke.Pharmacological stimulation and inhibition of insulin secretion in mouse islets lacking ATP-sensitive K+ channelsThe risk of overall mortality in patients with type 2 diabetes receiving glipizide, glyburide, or glimepiride monotherapy: a retrospective analysis.ATP-sensitive potassium channelopathies: focus on insulin secretionReversible changes in pancreatic islet structure and function produced by elevated blood glucose.Treating diabetes today: a matter of selectivity of sulphonylureas.Cell signalling in insulin secretion: the molecular targets of ATP, cAMP and sulfonylurea.The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1.Exercise-induced expression of cardiac ATP-sensitive potassium channels promotes action potential shortening and energy conservation.Mutations of the same conserved glutamate residue in NBD2 of the sulfonylurea receptor 1 subunit of the KATP channel can result in either hyperinsulinism or neonatal diabetesComputational and functional analyses of a small-molecule binding site in ROMK.Disruption of KATP channel expression in skeletal muscle by targeted oligonucleotide delivery promotes activity-linked thermogenesisReduction in number of sarcolemmal KATP channels slows cardiac action potential duration shortening under hypoxia.Subsets of ATP-sensitive potassium channel (KATP) inhibitors increase gap junctional intercellular communication in metastatic cancer cell lines independent of SUR expression.Reduction of cardiovascular morbidity and mortality in type 2 diabetes. A rational approach to hypoglycemic therapy.Pharmacological interventions that directly stimulate or modulate insulin secretion from pancreatic beta-cell: implications for the treatment of type 2 diabetes.Monogenic models: what have the single gene disorders taught us?Role for SUR2A ED domain in allosteric coupling within the K(ATP) channel complex.A Kir6.2 mutation causing severe functional effects in vitro produces neonatal diabetes without the expected neurological complicationsInvestigation of the Blood Glucose Lowering Potential of the Jamaican Momordica charantia (Cerasee) Fruit in Sprague-Dawley Rats.Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.Sulfonylurea therapy in two Korean patients with insulin-treated neonatal diabetes due to heterozygous mutations of the KCNJ11 gene encoding Kir6.2.Pharmacological rescue of trafficking-impaired ATP-sensitive potassium channels.Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells.Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating.
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Sulphonylurea action revisited: the post-cloning era.
@ast
Sulphonylurea action revisited: the post-cloning era.
@en
type
label
Sulphonylurea action revisited: the post-cloning era.
@ast
Sulphonylurea action revisited: the post-cloning era.
@en
prefLabel
Sulphonylurea action revisited: the post-cloning era.
@ast
Sulphonylurea action revisited: the post-cloning era.
@en
P1433
P1476
Sulphonylurea action revisited: the post-cloning era.
@en
P2093
P2888
P304
P356
10.1007/S00125-003-1143-3
P577
2003-06-18T00:00:00Z