Stress tolerance of misfolded carboxypeptidase Y requires maintenance of protein trafficking and degradative pathways
about
Mutation in archain 1, a subunit of COPI coatomer complex, causes diluted coat color and Purkinje cell degenerationCharacterization of an ERAD gene as VPS30/ATG6 reveals two alternative and functionally distinct protein quality control pathways: one for soluble Z variant of human alpha-1 proteinase inhibitor (A1PiZ) and another for aggregates of A1PiZ.Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality controlAlpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's modelsConserved and plant-unique strategies for overcoming endoplasmic reticulum stressAnalysis of quality control substrates in distinct cellular compartments reveals a unique role for Rpn4p in tolerating misfolded membrane proteins.The promoter of filamentation (POF1) protein from Saccharomyces cerevisiae is an ATPase involved in the protein quality control process.The conserved ATPase Get3/Arr4 modulates the activity of membrane-associated proteins in Saccharomyces cerevisiae.Limited ER quality control for GPI-anchored proteins.Genomewide analysis reveals novel pathways affecting endoplasmic reticulum homeostasis, protein modification and quality control.Yos9p and Hrd1p mediate ER retention of misfolded proteins for ER-associated degradation.The unfolded protein response is induced by the cell wall integrity mitogen-activated protein kinase signaling cascade and is required for cell wall integrity in Saccharomyces cerevisiae.Roles of molecular chaperones in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD)A Sox10 expression screen identifies an amino acid essential for Erbb3 function.Free oligosaccharides to monitor glycoprotein endoplasmic reticulum-associated degradation in Saccharomyces cerevisiaeModularity of the Hrd1 ERAD complex underlies its diverse client range.Evasion of endoplasmic reticulum surveillance makes Wsc1p an obligate substrate of Golgi quality controlInterplay of substrate retention and export signals in endoplasmic reticulum quality control.A nucleus-based quality control mechanism for cytosolic proteinsQuality and quantity control at the endoplasmic reticulum.Extracellular secretion of overexpressed glycosylphosphatidylinositol-linked cell wall protein Utr2/Crh2p as a novel protein quality control mechanism in Saccharomyces cerevisiae.Inositol deacylation by Bst1p is required for the quality control of glycosylphosphatidylinositol-anchored proteins.High-temperature cultivation of recombinant Pichia pastoris increases endoplasmic reticulum stress and decreases production of human interleukin-10.Molecular chaperones and substrate ubiquitination control the efficiency of endoplasmic reticulum-associated degradation.Mutant fibrinogen cleared from the endoplasmic reticulum via endoplasmic reticulum-associated protein degradation and autophagy: an explanation for liver disease.Kinetochore genes are required to fully activate secretory pathway expansion in S. cerevisiae under induced ER stress.Routing misfolded proteins through the multivesicular body (MVB) pathway protects against proteotoxicity.Endoplasmic reticulum stress triggers autophagy.Endoplasmic reticulum stress regulation of the Kar2p/BiP chaperone alleviates proteotoxicity via dual degradation pathways.Search and destroy: ER quality control and ER-associated protein degradation.A novel role in cytokinesis reveals a housekeeping function for the unfolded protein response.Identification of cytoplasmic residues of Sec61p involved in ribosome binding and cotranslational translocation.Single, context-specific glycans can target misfolded glycoproteins for ER-associated degradationTarget of rapamycin signaling mediates vacuolar fission caused by endoplasmic reticulum stress in Saccharomyces cerevisiae.The endoplasmic reticulum-associated degradation pathways of budding yeast.Stimulation of N-linked glycosylation and lipid-linked oligosaccharide synthesis by stress responses in metazoan cells.Heat shock response relieves ER stress.Analysis of COPII Vesicles Indicates a Role for the Emp47-Ssp120 Complex in Transport of Cell Surface Glycoproteins.Golgi-situated endoplasmic reticulum α-1, 2-mannosidase contributes to the retrieval of ERAD substrates through a direct interaction with γ-COP.How early studies on secreted and membrane protein quality control gave rise to the ER associated degradation (ERAD) pathway: the early history of ERAD.
P2860
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P2860
Stress tolerance of misfolded carboxypeptidase Y requires maintenance of protein trafficking and degradative pathways
description
2003 nî lūn-bûn
@nan
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
name
Stress tolerance of misfolded ...... cking and degradative pathways
@ast
Stress tolerance of misfolded ...... cking and degradative pathways
@en
type
label
Stress tolerance of misfolded ...... cking and degradative pathways
@ast
Stress tolerance of misfolded ...... cking and degradative pathways
@en
prefLabel
Stress tolerance of misfolded ...... cking and degradative pathways
@ast
Stress tolerance of misfolded ...... cking and degradative pathways
@en
P2860
P356
P1476
Stress tolerance of misfolded ...... cking and degradative pathways
@en
P2093
Davis T W Ng
Eric D Spear
P2860
P304
P356
10.1091/MBC.E02-11-0717
P577
2003-03-20T00:00:00Z