A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity.
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Limited trafficking of a neurotropic virus through inefficient retrograde axonal transport and the type I interferon responseViral mutation ratesArbovirus high fidelity variant loses fitness in mosquitoes and miceViral Polymerase-Helicase Complexes Regulate Replication Fidelity To Overcome Intracellular Nucleotide DepletionIncreased fidelity reduces poliovirus fitness and virulence under selective pressure in miceRNA-Dependent RNA Polymerases of Picornaviruses: From the Structure to Regulatory MechanismsCommon and unique features of viral RNA-dependent polymerasesViral quasispecies evolutionStructural dynamics as a contributor to error-prone replication by an RNA-dependent RNA polymerase.Lamivudine/Adefovir Treatment Increases the Rate of Spontaneous Mutation of Hepatitis B Virus in PatientsViral Determinants of Resistance to Treatment in Patients with Hepatitis CReplicative Homeostasis III: implications for antiviral therapy and mechanisms of response and non-responseGenetic Variability of Hepatitis C Virus before and after Combined Therapy of Interferon plus RibavirinReduced Ribavirin Antiviral Efficacy via Nucleoside Transporter-Mediated Drug ResistanceCounteracting Quasispecies Adaptability: Extinction of a Ribavirin-Resistant Virus Mutant by an Alternative Mutagenic TreatmentEffect of Ribavirin on the Mutation Rate and Spectrum of Hepatitis C Virus In VivoCrystal Structure of Poliovirus 3CD Protein: Virally Encoded Protease and Precursor to the RNA-Dependent RNA PolymeraseCrystal Structure of Coxsackievirus B3 3Dpol Highlights the Functional Importance of Residue 5 in Picornavirus PolymerasesStructure of Foot-and-Mouth Disease Virus Mutant Polymerases with Reduced Sensitivity to RibavirinA Multi-Step Process of Viral Adaptation to a Mutagenic Nucleoside Analogue by Modulation of Transition Types Leads to Extinction-EscapeStructural basis for active site closure by the poliovirus RNA-dependent RNA polymeraseStructures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contactsThe Crystal Structure of a Cardiovirus RNA-Dependent RNA Polymerase Reveals an Unusual Conformation of the Polymerase Active SiteMechanisms of viral mutationMutagenic Effects of Ribavirin on Hepatitis E Virus-Viral Extinction versus Selection of Fitness-Enhancing MutationsSelection for robustness in mutagenized RNA virusesPotential benefits of sequential inhibitor-mutagen treatments of RNA virus infectionsDoes mutational robustness inhibit extinction by lethal mutagenesis in viral populations?Cell type mediated resistance of vesicular stomatitis virus and Sendai virus to ribavirinCoronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeuticsSensitivity of a ribavirin resistant mutant of hepatitis C virus to other antiviral drugsVariation in RNA virus mutation rates across host cellsSequence-Specific Fidelity Alterations Associated with West Nile Virus Attenuation in MosquitoesLethal mutagenesis of bacteriaQuasispecies diversity determines pathogenesis through cooperative interactions in a viral populationSaffold virus, an emerging human cardiovirus.Drugs in development for influenza.Norovirus Polymerase Fidelity Contributes to Viral Transmission In Vivo.T-705 (favipiravir) induces lethal mutagenesis in influenza A H1N1 viruses in vitroMultiple host barriers restrict poliovirus trafficking in mice.
P2860
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P2860
A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelity.
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
A single mutation in polioviru ...... nalogs via increased fidelity.
@ast
A single mutation in polioviru ...... nalogs via increased fidelity.
@en
type
label
A single mutation in polioviru ...... nalogs via increased fidelity.
@ast
A single mutation in polioviru ...... nalogs via increased fidelity.
@en
prefLabel
A single mutation in polioviru ...... nalogs via increased fidelity.
@ast
A single mutation in polioviru ...... nalogs via increased fidelity.
@en
P2860
P356
P1476
A single mutation in polioviru ...... nalogs via increased fidelity.
@en
P2093
Julie K Pfeiffer
Karla Kirkegaard
P2860
P304
P356
10.1073/PNAS.1232294100
P407
P577
2003-05-16T00:00:00Z