Stoichiometric requirements for trapping and gating of Ca2+ release-activated Ca2+ (CRAC) channels by stromal interaction molecule 1 (STIM1). - Wikidata - wikimedia - TriplyDB

Stoichiometric requirements for trapping and gating of Ca2+ release-activated Ca2+ (CRAC) channels by stromal interaction molecule 1 (STIM1).

Stoichiometric requirements for trapping and gating of Ca2+ release-activated Ca2+ (CRAC) channels by stromal interaction molecule 1 (STIM1).

http://www.wikidata.org/entity/Q35164675

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Atomic force microscopy (AFM) imaging suggests that stromal interaction molecule 1 (STIM1) binds to Orai1 with sixfold symmetry STIM proteins: dynamic calcium signal transducers Permeation, selectivity and gating in store-operated CRAC channels The STIM1/Orai signaling machinery Molecular regulation of CRAC channels and their role in lymphocyte function Store-operated Orai channels: structure and function Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1)Pathophysiological Significance of Store-Operated Calcium Entry in Megakaryocyte Function: Opening New Paths for Understanding the Role of Calcium in Thrombopoiesis Fine tuning of cytosolic Ca (2+) oscillations Diseases caused by mutations in ORAI1 and STIM1 An essential and NSF independent role for α-SNAP in store-operated calcium entry Conformational Changes in the Orai1 C-Terminus Evoked by STIM1 Binding Single-molecule analysis of diffusion and trapping of STIM1 and Orai1 at endoplasmic reticulum-plasma membrane junctions.α-SNAP regulates dynamic, on-site assembly and calcium selectivity of Orai1 channels.Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis.Systems modeling of Ca(2+) homeostasis and mobilization in platelets mediated by IP3 and store-operated Ca(2+) entry Enhanced Ca²⁺ influx from STIM1-Orai1 induces muscle pathology in mouse models of muscular dystrophy.Sequential Steps of CRAC Channel Activation.Elevated Orai1 expression mediates tumor-promoting intracellular Ca2+ oscillations in human esophageal squamous cell carcinoma Molecular biophysics of Orai store-operated Ca2+ channels.Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states.STIM1L traps and gates Orai1 channels without remodeling the cortical ER Store-operated calcium channels: new perspectives on mechanism and function.Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels Activation of intracellular metabotropic glutamate receptor 5 in striatal neurons leads to up-regulation of genes associated with sustained synaptic transmission including Arc/Arg3.1 protein.Genetically targeted single-channel optical recording reveals multiple Orai1 gating states and oscillations in calcium influx.Termination and activation of store-operated cyclic AMP production.Store-operated Ca2+ Entry Mediated by Orai1 and TRPC1 Participates to Insulin Secretion in Rat β-Cells.Cooperative Binding of Stromal Interaction Molecule 1 (STIM1) to the N and C Termini of Calcium Release-activated Calcium Modulator 1 (Orai1).Orai1 pore residues control CRAC channel inactivation independently of calmodulin.The inactivation domain of STIM1 is functionally coupled with the Orai1 pore to enable Ca2+-dependent inactivation.Mutations of the Ca2+-sensing stromal interaction molecule STIM1 regulate Ca2+ influx by altered oligomerization of STIM1 and by destabilization of the Ca2+ channel Orai1 Orai3 TM3 point mutation G158C alters kinetics of 2-APB-induced gating by disulfide bridge formation with TM2 C101 Store-Operated Calcium Channel Complex in Postsynaptic Spines: A New Therapeutic Target for Alzheimer's Disease Treatment.Divergence of Ca(2+) selectivity and equilibrium Ca(2+) blockade in a Ca(2+) release-activated Ca(2+) channel.Enhanced store-operated Ca2+ influx and ORAI1 expression in ventricular fibroblasts from human failing heart.Ca(2+) release-activated Ca(2+) (CRAC) current, structure, and function.Open Sesame: treasure in store-operated calcium entry pathway for cancer therapy Orai channel pore properties and gating by STIM: implications from the Orai crystal structure.The functional contribution of calcium ion flux heterogeneity in T cells.

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P2860

Stoichiometric requirements for trapping and gating of Ca2+ release-activated Ca2+ (CRAC) channels by stromal interaction molecule 1 (STIM1).

http://www.wikidata.org/entity/Q35164675

description

2011 nî lūn-bûn

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2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2011 թվականի հուլիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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Stoichiometric requirements fo ...... nteraction molecule 1 (STIM1).

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Paul J Hoover

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P2860

Orai1 and STIM reconstitute store-operated calcium channel function

Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1

STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx

A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells

STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1

STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane

Amplification of CRAC current by STIM1 and CRACM1 (Orai1)

Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum.

STIM1, an essential and conserved component of store-operated Ca2+ channel function

Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation

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