Is the Achilles' heel for prostate cancer therapy a gain of function in androgen receptor signaling?
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RhoA as a mediator of clinically relevant androgen action in prostate cancer cellsIdentification of Notch-1 expression in the limbal basal epitheliumProstate cancer stem cells: the role of androgen and estrogen receptorsOncolytic adenovirus-mediated therapy for prostate cancerThe importance of non-nuclear AR signaling in prostate cancer progression and therapeutic resistanceTAF1 differentially enhances androgen receptor transcriptional activity via its N-terminal kinase and ubiquitin-activating and -conjugating domainsAck1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancerConcurrent HDAC and mTORC1 inhibition attenuate androgen receptor and hypoxia signaling associated with alterations in microRNA expressionA mathematical investigation of the multiple pathways to recurrent prostate cancer: comparison with experimental dataAccumulating progenitor cells in the luminal epithelial cell layer are candidate tumor initiating cells in a Pten knockout mouse prostate cancer modelLoss of androgen receptor-dependent growth suppression by prostate cancer cells can occur independently from acquiring oncogenic addiction to androgen receptor signalingCharacterisation of prostate cancer lesions in heterozygous Men1 mutant miceThe Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesisTransient induction of ING4 by Myc drives prostate epithelial cell differentiation and its disruption drives prostate tumorigenesis.Identification of a clinically relevant androgen-dependent gene signature in prostate cancerIncreased CK5/CK8-positive intermediate cells with stromal smooth muscle cell atrophy in the mice lacking prostate epithelial androgen receptorLow-calcium serum-free defined medium selects for growth of normal prostatic epithelial stem cells.Androgen receptor drives cellular senescence.Prostate epithelial stem and progenitor cells.Somatostatin derivative (smsDX) targets cellular metabolism in prostate cancer cells after androgen deprivation therapy.The role of CD133 in normal human prostate stem cells and malignant cancer-initiating cellsSHBG is an important factor in stemness induction of cells by DHT in vitro and associated with poor clinical features of prostate carcinomas.Androgen modulation of coregulator expression in prostate cancer cells.Androgen receptor as a licensing factor for DNA replication in androgen-sensitive prostate cancer cellsNuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis.Androgen receptor gene polymorphisms and alterations in prostate cancer: of humanized mice and men.Suppressed prostate epithelial development with impaired branching morphogenesis in mice lacking stromal fibromuscular androgen receptorAndrogen Receptor-Mediated Growth Suppression of HPr-1AR and PC3-Lenti-AR Prostate Epithelial Cells.Stem cells in prostate cancer initiation and progression.The evolving biology and treatment of prostate cancer.Regulation of androgen receptor signaling in prostate cancer.Estrogen and Androgen Hormone Levels Modulate the Expression of PIWI Interacting RNA in Prostate and Breast Cancer.TRPM8 channel as a novel molecular target in androgen-regulated prostate cancer cells.Targeting the unique methylation pattern of androgen receptor (AR) promoter in prostate stem/progenitor cells with 5-aza-2'-deoxycytidine (5-AZA) leads to suppressed prostate tumorigenesis.Androgen receptor variants and prostate cancer in humanized AR mice.Inhibition of androgen-independent prostate cancer cell growth is enhanced by combination therapy targeting Hedgehog and ErbB signalling.New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs. non-stem/progenitor cells.Current status of 5α-reductase inhibitors in prostate disease managementAndrogen receptor is a tumor suppressor and proliferator in prostate cancer.Androgen receptor (AR) suppresses normal human prostate epithelial cell proliferation via AR/β-catenin/TCF-4 complex inhibition of c-MYC transcription.
P2860
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P2860
Is the Achilles' heel for prostate cancer therapy a gain of function in androgen receptor signaling?
description
2003 nî lūn-bûn
@nan
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Is the Achilles' heel for pros ...... n androgen receptor signaling?
@ast
Is the Achilles' heel for pros ...... n androgen receptor signaling?
@en
type
label
Is the Achilles' heel for pros ...... n androgen receptor signaling?
@ast
Is the Achilles' heel for pros ...... n androgen receptor signaling?
@en
prefLabel
Is the Achilles' heel for pros ...... n androgen receptor signaling?
@ast
Is the Achilles' heel for pros ...... n androgen receptor signaling?
@en
P2093
P356
P1476
Is the Achilles' heel for pros ...... n androgen receptor signaling?
@en
P2093
Angelo M De Marzo
Ivan V Litvinov
John T Isaacs
P304
P356
10.1210/JC.2002-022038
P407
P577
2003-07-01T00:00:00Z