Peloruside- and laulimalide-resistant human ovarian carcinoma cells have βI-tubulin mutations and altered expression of βII- and βIII-tubulin isotypes.
about
An antimitotic and antivascular agent BPR0L075 overcomes multidrug resistance and induces mitotic catastrophe in paclitaxel-resistant ovarian cancer cellsLaulimalide and peloruside A inhibit mitosis of Saccharomyces cerevisiae by preventing microtubule depolymerisation-dependent steps in chromosome separation and nuclear positioning.Low-dose laulimalide represents a novel molecular probe for investigating microtubule organizationPeloruside, laulimalide, and noscapine interactions with beta-tubulin.Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities.Structural insight into the role of Gln293Met mutation on the Peloruside A/Laulimalide association with αβ-tubulin from molecular dynamics simulations, binding free energy calculations and weak interactions analysis.Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration.Peloruside A: a lead non-taxoid-site microtubule-stabilizing agent with potential activity against cancer, neurodegeneration, and autoimmune disease.Microtubule-stabilizing properties of the avocado-derived toxins (+)-(R)-persin and (+)-(R)-tetrahydropersin in cancer cells and activity of related synthetic analogs.Characterizing the laulimalide-peloruside binding site using site-directed mutagenesis of TUB2 in S. cerevisiae.Random mutagenesis of β-tubulin defines a set of dispersed mutations that confer paclitaxel resistance.Acquired resistance to peloruside A and laulimalide is associated with downregulation of vimentin in human ovarian carcinoma cells.Clinical Development of Anti-mitotic Drugs in Cancer.Peloruside A is a microtubule-stabilizing agent with exceptional anti-migratory properties in human endothelial cellsPaclitaxel resistance by random mutagenesis of α-tubulin.Cyclin A2 regulates homologous recombination DNA repair and sensitivity to DNA damaging agents and poly(ADP-ribose) polymerase (PARP) inhibitors in human breast cancer cells.Peloruside A, a microtubule-stabilizing agent, induces aneuploidy in ovarian cancer cells.Cyclin A2 regulates symmetrical mitotic spindle formation and centrosome amplification in human colon cancer cells
P2860
Q34770077-EF6BECC7-B1F1-411D-B2C0-44FA779100CDQ34993896-0448B5A1-EDC4-4FC7-9630-646F1BABA8E0Q36235535-D8914FA3-0F75-4762-A8A2-3045006F2AA3Q38021666-B9C0C150-34DD-4F7D-89C9-8D63AC3D278AQ38183686-17E56312-5FAE-449B-8AFF-23193E0A76CDQ38673001-BC183E69-0190-4EEA-9D6F-4E76EC78F0A6Q38705087-4579D772-33C0-4931-B042-5F474BE38359Q38729973-056FB698-A4E7-431B-A153-5484F052D077Q38787007-BB5F4C46-0CC3-4004-92D4-55C6E1E8F74AQ39070181-0A7F8EFC-BCE6-4FF3-9ADD-10B716029C1EQ39336478-E7063DCE-CC1B-4F60-8E73-22077C2EFC85Q39348373-115BA7C5-EB36-4FF7-8038-D4F8401FCF39Q39363642-A01AF6B4-5BF0-40A0-8A00-AC4CE433AC83Q41071363-A240C970-2238-4703-93AE-3FE7FC910B9CQ44561268-C32BB880-1C8C-4763-AF31-B3B2A159A54CQ47101574-F31B780C-6DE9-40DA-AE23-13916256D12DQ52870801-65A14441-E4E5-44D8-8FB2-FA54E5081AA0Q58775942-2B4CD546-C904-4A4B-9CC5-2CB1EAABA97E
P2860
Peloruside- and laulimalide-resistant human ovarian carcinoma cells have βI-tubulin mutations and altered expression of βII- and βIII-tubulin isotypes.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Peloruside- and laulimalide-re ...... II- and βIII-tubulin isotypes.
@ast
Peloruside- and laulimalide-re ...... II- and βIII-tubulin isotypes.
@en
type
label
Peloruside- and laulimalide-re ...... II- and βIII-tubulin isotypes.
@ast
Peloruside- and laulimalide-re ...... II- and βIII-tubulin isotypes.
@en
prefLabel
Peloruside- and laulimalide-re ...... II- and βIII-tubulin isotypes.
@ast
Peloruside- and laulimalide-re ...... II- and βIII-tubulin isotypes.
@en
P2093
P2860
P50
P1476
Peloruside- and laulimalide-re ...... βII- and βIII-tubulin isotypes
@en
P2093
Ada Gjyrezi
Ariane Chan
Arun Kanakkanthara
Aurora O'Brate
Ernest Hamel
Janet Crawford
John H Miller
Paraskevi Giannakakou
Peter T Northcote
Pisana Rawson
P2860
P304
P356
10.1158/1535-7163.MCT-10-1057
P577
2011-06-08T00:00:00Z