Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines. - Wikidata - wikimedia - TriplyDB

Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines.

Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines.

http://www.wikidata.org/entity/Q35174923

about

Calcium mishandling in diastolic dysfunction: mechanisms and potential therapies Molecular targets in heart failure gene therapy: current controversies and translational perspectives The potential of adeno-associated viral vectors for gene delivery to muscle tissue.A titratable two-step transcriptional amplification strategy for targeted gene therapy based on ligand-induced intramolecular folding of a mutant human estrogen receptor Molecular dissection of human Argonaute proteins by DNA shuffling.Altered myocardial calcium cycling and energetics in heart failure--a rational approach for disease treatment.A novel artificial microRNA expressing AAV vector for phospholamban silencing in cardiomyocytes improves Ca2+ uptake into the sarcoplasmic reticulum.The AAV vector toolkit: poised at the clinical crossroads Rheostatic Regulation of the SERCA/Phospholamban Membrane Protein Complex Using Non-Coding RNA and Single-Stranded DNA oligonucleotides.Embedding siRNA sequences targeting apolipoprotein B100 in shRNA and miRNA scaffolds results in differential processing and in vivo efficacy Studies of efficacy and liver toxicity related to adeno-associated virus-mediated RNA interference.Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines.Recombinant AAV as a platform for translating the therapeutic potential of RNA interference.Cardiac gene therapy in large animals: bridge from bench to bedside.Gene and cytokine therapy for heart failure: molecular mechanisms in the improvement of cardiac function.Cardiac gene therapy with adeno-associated virus-based vectors.A designed zinc-finger transcriptional repressor of phospholamban improves function of the failing heart.Use of Adeno-Associated Virus Vector for Cardiac Gene Delivery in Large-Animal Surgical Models of Heart Failure.The dose can make the poison: lessons learned from adverse in vivo toxicities caused by RNAi overexpression.Design, Characterization, and Lead Selection of Therapeutic miRNAs Targeting Huntingtin for Development of Gene Therapy for Huntington's Disease.shRNA-induced saturation of the microRNA pathway in the rat brain.Safe and Efficient Silencing with a Pol II, but Not a Pol lII, Promoter Expressing an Artificial miRNA Targeting Human Huntingtin.Translation of MicroRNA-Based Huntingtin-Lowering Therapies from Preclinical Studies to the Clinic.

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P2860

Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines.

http://www.wikidata.org/entity/Q35174923

description

2011 nî lūn-bûn

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2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2011 թվականի հունիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Cardiac gene transfer of short ...... cellular toxicity in canines.

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Cardiac gene transfer of short ...... cellular toxicity in canines.

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type

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Cardiac gene transfer of short ...... cellular toxicity in canines.

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Cardiac gene transfer of short ...... cellular toxicity in canines.

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Cardiac gene transfer of short ...... cellular toxicity in canines.

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Cardiac gene transfer of short ...... cellular toxicity in canines.

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Human Gene Therapy

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Cardiac gene transfer of short ...... cellular toxicity in canines.

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Caryn Reynolds

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Daniel Hui

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Elanor Withnall

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George Buchlis

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Gretchen E Singletary

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Guangping Gao

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H Lee Sweeney

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James M Wilson

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Jeffrey Gazzara

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Katherine A High

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P2860

A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.

Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20

A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure

Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis

Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2

The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

Control of stress-dependent cardiac growth and gene expression by a microRNA

MicroRNA-133 controls cardiac hypertrophy

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10.1089/HUM.2011.035

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8

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22

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