Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB
about
Recent advances toward a molecular mechanism of efflux pump inhibitionMechanism of coupling drug transport reactions located in two different membranesStructural basis of RND-type multidrug exportersRelocation of active site carboxylates in major facilitator superfamily multidrug transporter LmrP reveals plasticity in proton interactionsATP-dependent substrate transport by the ABC transporter MsbA is proton-coupledNanobodies as Probes for Protein Dynamics in Vitro and in Cells.Architecture and roles of periplasmic adaptor proteins in tripartite efflux assembliesAn allosteric transport mechanism for the AcrAB-TolC multidrug efflux pumpStructural Symmetry in Membrane Proteins.Lack of AcrB Efflux Function Confers Loss of Virulence on Salmonella enterica Serovar Typhimurium.Repressive mutations restore function-loss caused by the disruption of trimerization in Escherichia coli multidrug transporter AcrB.The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.Interaction of antibacterial compounds with RND efflux pumps in Pseudomonas aeruginosaReversal of the Drug Binding Pocket Defects of the AcrB Multidrug Efflux Pump Protein of Escherichia coli.Stepwise substrate translocation mechanism revealed by free energy calculations of doxorubicin in the multidrug transporter AcrB.Aminoacyl β-naphthylamides as substrates and modulators of AcrB multidrug efflux pumpTripartite assembly of RND multidrug efflux pumps.Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxinMolecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivativesStructure and mechanism of the ATP synthase membrane motor inferred from quantitative integrative modeling.AcrB-AcrA Fusion Proteins That Act as Multidrug Efflux Transporters.Optimization of a novel series of pyranopyridine RND efflux pump inhibitors.Unconventional Coupling between Ligand Recognition and Allosteric Control in the Multidrug Resistance Gene Regulator, BmrR.New Roads Leading to Old Destinations: Efflux Pumps as Targets to Reverse Multidrug Resistance in Bacteria.The diverse family of MmpL transporters in mycobacteria: from regulation to antimicrobial developments.Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB.Structures and transport dynamics of a Campylobacter jejuni multidrug efflux pump.Molecular Rationale behind the Differential Substrate Specificity of Bacterial RND Multi-Drug Transporters.Structure-Function Profile of MmpL3, the Essential Mycolic Acid Transporter from Mycobacterium tuberculosis.Energy-coupling mechanism of the multidrug resistance transporter AcrB: Evidence for membrane potential-driving hypothesis through mutagenic analysis.Hoisting-Loop in Bacterial Multidrug Exporter AcrB Is a Highly Flexible Hinge That Enables the Large Motion of the Subdomains.Synergy between Active Efflux and Outer Membrane Diffusion Defines Rules of Antibiotic Permeation into Gram-Negative Bacteria.Crystal structure of tripartite-type ABC transporter MacB from Acinetobacter baumannii.Dynamics of Intact MexAB-OprM Efflux Pump: Focusing on the MexA-OprM Interface.Constant pH Molecular Dynamics Reveals How Proton Release Drives the Conformational Transition of a Transmembrane Efflux Pump.Energy coupling mechanisms of AcrB-like RND transporters.High-Resolution Crystallographic Analysis of AcrB Using Designed Ankyrin Repeat Proteins (DARPins).Mechanisms of envelope permeability and antibiotic influx and efflux in Gram-negative bacteria.[Antibiotic transport and membrane permeability: new insights to fight bacterial resistance].Energetics and conformational pathways of functional rotation in the multidrug transporter AcrB.
P2860
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P2860
Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB
description
2014 nî lūn-bûn
@nan
2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Coupling of remote alternating ...... the multidrug efflux pump AcrB
@ast
Coupling of remote alternating ...... the multidrug efflux pump AcrB
@en
type
label
Coupling of remote alternating ...... the multidrug efflux pump AcrB
@ast
Coupling of remote alternating ...... the multidrug efflux pump AcrB
@en
prefLabel
Coupling of remote alternating ...... the multidrug efflux pump AcrB
@ast
Coupling of remote alternating ...... the multidrug efflux pump AcrB
@en
P2093
P2860
P356
P1433
P1476
Coupling of remote alternating ...... the multidrug efflux pump AcrB
@en
P2093
José D Faraldo-Gómez
Kay Diederichs
Klaas M Pos
Lorenz Brandstätter
Markus A Seeger
Thomas Eicher
Wenchang Zhou
P2860
P356
10.7554/ELIFE.03145
P407
P577
2014-09-19T00:00:00Z