The metabolism of diclofenac--enzymology and toxicology perspectives.
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Stereoselective flunoxaprofen-S-acyl-glutathione thioester formation mediated by acyl-CoA formation in rat hepatocytesEvidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in manDiclofenac hypersensitivity: antibody responses to the parent drug and relevant metabolitesSex differences in liver toxicity-do female and male human primary hepatocytes react differently to toxicants in vitro?Analysis of endogenous glutathione-adducts and their metabolites.Stable-isotope dilution LC–MS for quantitative biomarker analysis.Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System.Suppression of gastric acid increases the risk of developing immunoglobulin E-mediated drug hypersensitivity: human diclofenac sensitization and a murine sensitization modelLiver enzyme induction and inhibition: implications for anaesthesia.Metabolic profiling of new synthetic cannabinoids AMB and 5F-AMB by human hepatocyte and liver microsome incubations and high-resolution mass spectrometry.Cytochrome P450 2C8 pharmacogenetics: a review of clinical studiesMetabolic activation and analgesic effect of flupirtine in healthy subjects, influence of the polymorphic NAT2, UGT1A1 and GSTP1.Enantioselective pharmacokinetics of ibuprofen and involved mechanisms.In Silico Predictions of Drug - Drug Interactions Caused by CYP1A2, 2C9 and 3A4 Inhibition - a Comparative Study of Virtual Screening Performance.Role of intestinal cytochrome p450 enzymes in diclofenac-induced toxicity in the small intestine.Role of biotransformation in drug-induced toxicity: influence of intra- and inter-species differences in drug metabolism.Minimising the potential for metabolic activation in drug discovery.Analysis of the Functional Polymorphism in the Cytochrome P450 CYP2C8 Gene rs11572080 with Regard to Colorectal Cancer Risk.Drug metabolite profiling and elucidation of drug-induced hepatotoxicity.Cytochromes P450: a structure-based summary of biotransformations using representative substrates.Pharmacogenetics of analgesics: toward the individualization of prescription.Formed and preformed metabolites: facts and comparisons.Rapid LC-MS drug metabolite profiling using microsomal enzyme bioreactors in a parallel processing format.Drug-induced liver injury: insights from genetic studies.Metabolic bioactivation and drug-related adverse effects: current status and future directions from a pharmaceutical research perspective.Animal models of idiosyncratic drug-induced liver injury--current status.The primary role of hepatic metabolism in idiosyncratic drug-induced liver injury.Pharmacogenomics of acetylsalicylic acid and other nonsteroidal anti-inflammatory agents: clinical implications.Streptomyces cytochromes P450: applications in drug metabolism.Detecting reactive drug metabolites for reducing the potential for drug toxicity.How polymorphisms of the cytochrome P450 genes affect ibuprofen and diclofenac metabolism and toxicity.Diclofenac-induced apoptosis in the neuroblastoma cell line SH-SY5Y: possible involvement of the mitochondrial superoxide dismutaseDetermination of diclofenac concentrations in human plasma using a sensitive gas chromatography mass spectrometry method.The guinea-pig expresses functional CYP2C and P-glycoprotein: further validation of its usefulness in drug biotransformation/transport studies.Nephroprotective Effect of the Leaves of Aloe barbadensis (Aloe Vera) against Toxicity Induced by Diclofenac Sodium in Albino Rabbits.Patient risk factors and adverse drug interactions in the treatment of acute gouty arthritis in the elderly: a case report.Biochemical mechanisms in drug-induced liver injury: certainties and doubts.Diclofenac toxicity in human intestine ex vivo is not related to the formation of intestinal metabolites.Multiple organ failure after an overdose of less than 0.4 mg/kg of colchicine: role of coingestants and drugs during intensive care management.Human monocyte-derived cells with individual hepatocyte characteristics: a novel tool for personalized in vitro studies.
P2860
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P2860
The metabolism of diclofenac--enzymology and toxicology perspectives.
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The metabolism of diclofenac--enzymology and toxicology perspectives.
@ast
The metabolism of diclofenac--enzymology and toxicology perspectives.
@en
type
label
The metabolism of diclofenac--enzymology and toxicology perspectives.
@ast
The metabolism of diclofenac--enzymology and toxicology perspectives.
@en
prefLabel
The metabolism of diclofenac--enzymology and toxicology perspectives.
@ast
The metabolism of diclofenac--enzymology and toxicology perspectives.
@en
P356
P1476
The metabolism of diclofenac--enzymology and toxicology perspectives.
@en
P2093
P304
P356
10.2174/1389200033489398
P407
P577
2003-08-01T00:00:00Z