Metal impurities cause false positives in high-throughput screening campaigns - Wikidata - wikimedia - TriplyDB

Metal impurities cause false positives in high-throughput screening campaigns

Metal impurities cause false positives in high-throughput screening campaigns

http://www.wikidata.org/entity/Q35181932

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Discovery and resupply of pharmacologically active plant-derived natural products: A review Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?A cell-free fluorometric high-throughput screen for inhibitors of Rtt109-catalyzed histone acetylation The essential roles of chemistry in high-throughput screening triage PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS.Chemical Probe Identification Platform for Orphan GPCRs Using Focused Compound Screening: GPR39 as a Case Example.Identifying initiation and elongation inhibitors of dengue virus RNA polymerase in a high-throughput lead-finding campaign.Mitigating risk in academic preclinical drug discovery.Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR.Oxidative Reactivities of 2-Furylquinolines: Ubiquitous Scaffolds in Common High-Throughput Screening Libraries.Non-stoichiometric inhibition in integrated lead finding - a literature review.Quality Issues with Public Domain Chemogenomics Data.Matching the power of high throughput screening to the chemical diversity of natural products Oncogenic protein interfaces: small molecules, big challenges.Natural products for human health: an historical overview of the drug discovery approaches.The importance of triaging in determining the quality of output from high-throughput screening.Screening Pools of Compounds against Multiple Endogenously Expressed Targets in a Chemoproteomics Binding Assay.HPLC biogram analysis: a powerful tool used for hit confirmation in early drug discovery.Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements.Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017-Utility and Limitations.A False-Positive Screening Hit in Fragment-Based Lead Discovery: Watch out for the Red Herring.Mild-Base-Promoted Arylation of (Hetero)Arenes with Anilines.Sulfoxide-directed metal-free cross-couplings in the expedient synthesis of benzothiophene-based components of materials.The synthesis of O-1 to O-6 substituted positional isomers of D-glucose-thioether ligands and their ruthenium polypyridyl conjugates Reproducibility: Check your chemistry

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P2860

Metal impurities cause false positives in high-throughput screening campaigns

http://www.wikidata.org/entity/Q35181932

description

2012 nî lūn-bûn

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2012 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2012年の論文

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2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

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2012年论文

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name

Metal impurities cause false positives in high-throughput screening campaigns

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Metal impurities cause false positives in high-throughput screening campaigns

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type

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Metal impurities cause false positives in high-throughput screening campaigns

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Metal impurities cause false positives in high-throughput screening campaigns

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prefLabel

Metal impurities cause false positives in high-throughput screening campaigns

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Metal impurities cause false positives in high-throughput screening campaigns

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ACS Medicinal Chemistry Letters

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Metal impurities cause false positives in high-throughput screening campaigns

@en

P2093

Ann Petersen

http://www.w3.org/2001/XMLSchema#string

Arjun Narayanan

http://www.w3.org/2001/XMLSchema#string

Binh Vu

http://www.w3.org/2001/XMLSchema#string

Hong Qian

http://www.w3.org/2001/XMLSchema#string

Johannes C Hermann

http://www.w3.org/2001/XMLSchema#string

John Menke

http://www.w3.org/2001/XMLSchema#string

Kelly M George

http://www.w3.org/2001/XMLSchema#string

Lin Gao

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Linghao Niu

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Nancy-Ellen Haynes

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P2860

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds

Design of potent selective zinc-mediated serine protease inhibitors

Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis

Molecular complexity and its impact on the probability of finding leads for drug discovery.

NMR-based quality control approach for the identification of false positives and false negatives in high throughput screening.

Learning from the data: mining of large high-throughput screening databases.

High-throughput assays for promiscuous inhibitors.

Profiling the NIH Small Molecule Repository for compounds that generate H2O2 by redox cycling in reducing environments.

Biosensor-based small molecule fragment screening with biolayer interferometry.

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197-200

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scholarly article

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10.1021/ML3003296

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2

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4

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Charles A Wartchow

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2012-12-12T00:00:00Z

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24900642

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4027514

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