Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia. - Wikidata - wikimedia - TriplyDB

Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia.

Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia.

http://www.wikidata.org/entity/Q35182716

about

Localization and upregulation of survivin in cancer health disparities: a clinical perspective Survivin - The inconvenient IAP A novel small molecule FL118 that selectively inhibits survivin, Mcl-1, XIAP and cIAP2 in a p53-independent manner, shows superior antitumor activity An intravenous (i.v.) route-compatible formulation of FL118, a survivin, Mcl-1, XIAP, and cIAP2 selective inhibitor, improves FL118 antitumor efficacy and therapeutic index (TI)Antibody-siRNA conjugates: drugging the undruggable for anti-leukemic therapy.CBP/catenin antagonist safely eliminates drug-resistant leukemia-initiating cells.A phase I study of EZN-3042, a novel survivin messenger ribonucleic acid (mRNA) antagonist, administered in combination with chemotherapy in children with relapsed acute lymphoblastic leukemia (ALL): a report from the therapeutic advances in childho Targeting survivin in cancer: novel drug development approaches.MicroRNA regulation and therapeutic targeting of survivin in cancer.Sp1 and c-Myc modulate drug resistance of leukemia stem cells by regulating survivin expression through the ERK-MSK MAPK signaling pathway Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma YM155 potently kills acute lymphoblastic leukemia cells through activation of the DNA damage pathway Epigenetic reprogramming reverses the relapse-specific gene expression signature and restores chemosensitivity in childhood B-lymphoblastic leukemia.Bioluminescence imaging of leukemia cell lines in vitro and in mouse xenografts: effects of monoclonal and polyclonal cell populations on intensity and kinetics of photon emission Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy.O-acetylated N-acetylneuraminic acid as a novel target for therapy in human pre-B acute lymphoblastic leukemia.Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.Pharmacogenomic considerations of xenograft mouse models of acute leukemia.Inhibitor of apoptosis proteins in pediatric leukemia: molecular pathways and novel approaches to therapy.Hypoxic tumor microenvironment in advanced retinoblastoma.FL118, a novel survivin inhibitor, wins the battle against drug-resistant and metastatic lung cancers through inhibition of cancer stem cell-like properties.The role of the Wnt signaling pathway in cancer stem cells: prospects for drug development.Survivin isoform expression in arsenic trioxide-treated acute promyelocytic leukemia cell line and patients: The odd expression pattern of survivin-2α.Anti-leukemic effects of the V-ATPase inhibitor Archazolid A.BIRC5/Survivin as a target for glycolysis inhibition in high-stage neuroblastoma.Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia.Survivin inhibition via EZN-3042 in canine lymphoma and osteosarcoma.CBP/Catenin antagonists: Targeting LSCs' Achilles heel.Survivin inhibition by an interacting recombinant peptide, derived from the human ferritin heavy chain, impedes tumor cell growth.Significance of survivin expression: Prognostic value and survival in stage III non-small cell lung cancer.Cytotoxicity of CD56-positive lymphocytes against autologous B-cell precursor acute lymphoblastic leukemia cells Survivin-specific small interfering RNAs enhance sensitivity of glioma U-87MG cells to paclitaxel by promoting apoptosis.Effects of the small-molecule inhibitor of integrin α4, TBC3486, on pre-B-ALL cells.Over-expression of survivin and VEGF in small-cell lung cancer may predict the poorer prognosis.The T-ALL related gene BCL11B regulates the initial stages of human T-cell differentiation.Effects of CD49d-targeted antisense-oligonucleotide on α4 integrin expression and function of acute lymphoblastic leukemia cells: Results of in vitro and in vivo studies.ATF4 activation by the p38MAPK-eIF4E axis mediates apoptosis and autophagy induced by selenite in Jurkat cells.Camptothecin (CPT) and its derivatives are known to target topoisomerase I (Top1) as their mechanism of action: did we miss something in CPT analogue molecular targets for treating human disease such as cancer?Inhibitors of apoptosis: clinical implications in cancer.Fish-oil-derived eicosapentaenoic acid decreases survivin expression and induces wt-p53 accumulation with caspase-3 activation in acute lymphoblastic leukemia cells.

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Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia.

http://www.wikidata.org/entity/Q35182716

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2011 nî lūn-bûn

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2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2011 թվականի հունիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia.

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Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia.

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Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia.

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Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia.

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Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia.

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Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia.

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Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia.

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Edward M Conway

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Eugene Park

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Eun Ji Gang

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Eun-Suk Kang

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Ganesan Keerthivasan

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Hong Hoe Koo

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John Crispino

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Lars Klemm

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Louis Pelus

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Markus Müschen

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P2860

Control of apoptosis and mitotic spindle checkpoint by survivin

Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain

HBXIP functions as a cofactor of survivin in apoptosis suppression

Final stages of cytokinesis and midbody ring formation are controlled by BRUCE

Solution structure of human survivin and its binding interface with Smac/Diablo

cIAP1 Localizes to the nuclear compartment and modulates the cell cycle

Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis

Direct interaction between survivin and Smac/DIABLO is essential for the anti-apoptotic activity of survivin during taxol-induced apoptosis

An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7

Validating survivin as a cancer therapeutic target

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2191-2199

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10.1182/BLOOD-2011-04-351239

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