Glucose-dependent insulinotropic polypeptide analogues and their therapeutic potential for the treatment of obesity-diabetes.
about
Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor[Ser2]- and [SerP2] incretin analogs: comparison of dipeptidyl peptidase IV resistance and biological activities in vitro and in vivo.Antidiabetic potential of two novel fatty acid derivatised, N-terminally modified analogues of glucose-dependent insulinotropic polypeptide (GIP): N-AcGIP(LysPAL16) and N-AcGIP(LysPAL37).Decreased neuronal bursting and phase synchrony in the hippocampus of streptozotocin diabetic ratsA novel long-acting glucose-dependent insulinotropic peptide analogue: enhanced efficacy in normal and diabetic rodentsGIP does not potentiate the antidiabetic effects of GLP-1 in hyperglycemic patients with type 2 diabetesTargeting beta-cell cyclic 3'5' adenosine monophosphate for the development of novel drugs for treating type 2 diabetes mellitus. A review.Obesity and the role of gut and adipose hormones in female reproduction.Daily administration of the GIP-R antagonist (Pro3)GIP in streptozotocin-induced diabetes suggests that insulin-dependent mechanisms are critical to anti-obesity-diabetes actions of (Pro3)GIP.Antagonistic effects of two novel GIP analogs, (Hyp3)GIP and (Hyp3)GIPLys16PAL, on the biological actions of GIP and longer-term effects in diabetic ob/ob mice.A whey protein hydrolysate promotes insulinotropic activity in a clonal pancreatic β-cell line and enhances glycemic function in ob/ob mice.A stable analogue of glucose-dependent insulinotropic polypeptide, GIP(LysPAL16), enhances functional differentiation of mouse embryonic stem cells into cells expressing islet-specific genes and hormones.Using the lymph fistula rat model to study the potentiation of GIP secretion by the ingestion of fat and glucose.Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice.Comparison of the independent and combined metabolic effects of subchronic modulation of CCK and GIP receptor action in obesity-related diabetes.A novel GIP analogue, ZP4165, enhances glucagon-like peptide-1-induced body weight loss and improves glycaemic control in rodents.Exenatide upregulates gene expression of glucagon-like peptide-1 receptor and nerve growth factor in streptozotocin/nicotinamide-induced diabetic mice.Exenatide enhances cognitive performance and upregulates neurotrophic factor gene expression levels in diabetic mice.Gut hormone polyagonists for the treatment of type 2 diabetes.Characterization of 111In-labeled Glucose-Dependent Insulinotropic Polypeptide as a Radiotracer for Neuroendocrine Tumors.A DPP-IV-resistant triple-acting agonist of GIP, GLP-1 and glucagon receptors with potent glucose-lowering and insulinotropic actions in high-fat-fed mice.
P2860
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P2860
Glucose-dependent insulinotropic polypeptide analogues and their therapeutic potential for the treatment of obesity-diabetes.
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
name
Glucose-dependent insulinotrop ...... treatment of obesity-diabetes.
@ast
Glucose-dependent insulinotrop ...... treatment of obesity-diabetes.
@en
type
label
Glucose-dependent insulinotrop ...... treatment of obesity-diabetes.
@ast
Glucose-dependent insulinotrop ...... treatment of obesity-diabetes.
@en
prefLabel
Glucose-dependent insulinotrop ...... treatment of obesity-diabetes.
@ast
Glucose-dependent insulinotrop ...... treatment of obesity-diabetes.
@en
P50
P1476
Glucose-dependent insulinotrop ...... treatment of obesity-diabetes
@en
P2093
Finbarr P M O'Harte
P304
P356
10.1016/S0006-291X(03)01361-5
P407
P577
2003-08-01T00:00:00Z