Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cells. - Wikidata - wikimedia - TriplyDB

Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cells.

Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cells.

http://www.wikidata.org/entity/Q35197906

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The role of naive T cell precursor frequency and recruitment in dictating immune response magnitude Tracking antigen-specific CD4+ T cells throughout the course of chronic Leishmania major infection in resistant mice.Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3).Virus-specific regulatory T cells ameliorate encephalitis by repressing effector T cell functions from priming to effector stages The same self-peptide selects conventional and regulatory CD4⁺ T cells with identical antigen receptors.Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns.Optimal T-cell receptor affinity for inducing autoimmunity.In silico modeling of Itk activation kinetics in thymocytes suggests competing positive and negative IP4 mediated feedbacks increase robustness.Cis-acting pathways selectively enforce the non-immunogenicity of shed placental antigen for maternal CD8 T cells.The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function.T cell receptor cross-reactivity between similar foreign and self peptides influences naive cell population size and autoimmunity.Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8(+) T Lymphocytes.Defective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in mice Bi-Allelic TCRα or β Recombination Enhances T Cell Development but Is Dispensable for Antigen Responses and Experimental Autoimmune Encephalomyelitis.Cross-Generational Reproductive Fitness Enforced by Microchimeric Maternal Cells.Common clonal origin of central and resident memory T cells following skin immunization A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self.Pregnancy imprints regulatory memory that sustains anergy to fetal antigen.CD4+ T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion.Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen.CD4+ T cell persistence and function after infection are maintained by low-level peptide:MHC class II presentation.Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection.Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12.Tolerance to noninherited maternal antigens, reproductive microchimerism and regulatory T cell memory: 60 years after 'Evidence for actively acquired tolerance to Rh antigens'.Apoptosis in response to microbial infection induces autoreactive TH17 cells Programmed Death-1 Culls Peripheral Accumulation of High-Affinity Autoreactive CD4 T Cells to Protect against Autoimmunity Cutting edge: committed Th1 CD4+ T cell differentiation blocks pregnancy-induced Foxp3 expression with antigen-specific fetal loss.Flow-cytometric analysis of rare antigen-specific T cells.Foxp3⁺ T(reg) cells in humoral immunity.A population biological approach to understanding the maintenance and loss of the T-cell repertoire during aging.T-cell selection and intestinal homeostasis.TCR signal quantity and quality in CD4(+) T cell differentiation.Delayed Cytotoxic T Lymphocyte-Associated Protein 4-Immunoglobulin Treatment Reverses Ongoing Alloantibody Responses and Rescues Allografts From Acute Rejection CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ T helper 1 cell differentiation Development of T-cell tolerance utilizes both cell-autonomous and cooperative presentation of self-antigen.Immunologic characteristics of HIV-infected individuals who make broadly neutralizing antibodies.Relationship between CD4 Regulatory T Cells and Anergy In Vivo.Selective culling of high avidity antigen-specific CD4+ T cells after virulent Salmonella infection.Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage.Successful Treatment of T Cell-Mediated Acute Rejection with Delayed CTLA4-Ig in Mice.

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Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cells.

http://www.wikidata.org/entity/Q35197906

description

2011 nî lūn-bûn

@nan

2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի օգոստոսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Quantitative impact of thymic ...... lass II-specific CD4+ T cells.

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Quantitative impact of thymic ...... lass II-specific CD4+ T cells.

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Quantitative impact of thymic ...... lass II-specific CD4+ T cells.

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Quantitative impact of thymic ...... lass II-specific CD4+ T cells.

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Proceedings of the National Academy of Sciences of the United States of America

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Quantitative impact of thymic ...... lass II-specific CD4+ T cells.

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H Hamlet Chu

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James J Moon

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Jennifer L McClaren

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Marc K Jenkins

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Paul G Thomas

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Thomas H Oguin

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P2860

Control of regulatory T cell development by the transcription factor Foxp3

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Regulatory T cell lineage specification by the forkhead transcription factor foxp3

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

The timing of TCR alpha expression critically influences T cell development and selection

Affinity-based selection of regulatory T cells occurs independent of agonist-mediated induction of Foxp3 expression

Positive and negative selection of T cells.

Paired analysis of TCRα and TCRβ chains at the single-cell level in mice.

High prevalence of low affinity peptide-MHC II tetramer-negative effectors during polyclonal CD4+ T cell responses

T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire.

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